发明申请
- 专利标题： ENZYME FOR THE PRODUCTION OF OPTICALLY PURE 3-QUINUCLIDINOL
- 专利标题（中）： 用于生产光学纯度3-喹啉酮的酶
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申请号： US13809306申请日： 2011-07-14
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公开(公告)号： US20140147896A1公开(公告)日： 2014-05-29
- 发明人: Rupal Joshi , Anita Nair , Anita Ramrakhiani , Sanjeev Kumar Mendiratta , Umang Trivedi
- 申请人： CADILA HEALTHCARE LIMITED
- 申请人地址： IN Ahmedabad
- 专利权人： CADILA HEALTHCARE LIMITED
- 当前专利权人： CADILA HEALTHCARE LIMITED
- 当前专利权人地址： IN Ahmedabad
- 优先权： IN2028/MUM/2010 20100714
- 国际申请： PCT/IN2011/000469 WO 20110714
- 主分类号： C12P17/18
- IPC分类号： C12P17/18 ; C12N9/04 ; C12N9/02
摘要：
The present invention provides a process for production of optically pure quinuclidinol of formula-(I) by reduction of quinuclidinone of formula-(II) in presence of suitable oxidoreductase enzyme derived from Saccharomyces species. Formula (II, I) Moreover, the present enzyme works in presence of cofactor NADP where the cofactor is regenerated by suitable system. The present invention also provides a recombinant vector containing genes co expressing suitable polypeptides having oxido-reductase activity and polypeptide having capacity to regenerate the co-factor. The said vector is transformed in suitable host cell.
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