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    Purification Process for PTH
    3.
    发明申请
    Purification Process for PTH 审中-公开
    PTH的净化过程

    公开(公告)号：US20160200792A1

    公开(公告)日：2016-07-14

    申请号：US14912984

    申请日：2014-08-21

    申请人： CADILA HEALTHCARE LIMITED

    发明人： Sanjeev Kumar Mendiratta ,  Sanjay Bandyopadhyay ,  Avanish Kumar Singh

    IPC分类号： C07K14/635 ,  B01D15/36 ,  C07K1/18

    CPC分类号： C07K14/635 ,  B01D15/363 ,  C07K1/18

    摘要： The present invention relates to improved method for purification of a recombinant parathyroid hormone (rhPTH1-34 or teriparatide), said process for purification of parathyroid hormone comprising following essential steps: (a) Enzymatic cleavage; (b) anion exchange chromatography, followed by other suitable purification steps; wherein step (a) and (b) can be carried out in any order.

    摘要翻译： 本发明涉及用于纯化重组甲状旁腺激素（rhPTH1-34或特立帕定）的改进方法，所述方法用于纯化甲状旁腺激素，其包括以下必要步骤：（a）酶切; （b）阴离子交换层析，然后进行其他合适的纯化步骤; 其中步骤（a）和（b）可以以任何顺序进行。

    NOVEL PURIFICATION PROCESS OF GONADOTROPIN
    5.
    发明申请
    NOVEL PURIFICATION PROCESS OF GONADOTROPIN 审中-公开
    GONADOTROPIN的新型纯化方法

    公开(公告)号：US20170029482A1

    公开(公告)日：2017-02-02

    申请号：US15303888

    申请日：2015-04-17

    申请人： CADILA HEALTHCARE LIMITED

    发明人： Sanjeev Kumar Mendiratta ,  Sanjay Bandyopadhyay ,  Avanish K. Singh ,  Mithra S. Reddy

    IPC分类号： C07K14/59

    CPC分类号： C07K14/59

    摘要： The present invention provides an improved method for the purification of desired gonadotropin from a crude mixture containing at least one contaminating protein. The process of purification of the desired gonadotropin according to the present invention comprises use of an affinity chromatography as the first column purification step, prior to use of any column chromatography steps for further purification. Such purification process may further include ion exchange and/or hydrophobic interaction chromatography step to obtain substantially purified gonadotropin protein with desired isoforms profile.

    摘要翻译： 本发明提供了一种从含有至少一种污染蛋白质的粗混合物中纯化所需促性腺激素的改进方法。 在使用任何柱色谱步骤进一步纯化之前，根据本发明的纯化所需促性腺激素的方法包括使用亲和层析作为第一柱纯化步骤。 这样的纯化方法还可以包括离子交换和/或疏水相互作用层析步骤，以获得具有所需同种型谱的基本上纯化的促性腺激素蛋白。

    ENZYME FOR THE PRODUCTION OF OPTICALLY PURE 3-QUINUCLIDINOL
    9.
    发明申请
    ENZYME FOR THE PRODUCTION OF OPTICALLY PURE 3-QUINUCLIDINOL 审中-公开
    用于生产光学纯度3-喹啉酮的酶

    公开(公告)号：US20140147896A1

    公开(公告)日：2014-05-29

    申请号：US13809306

    申请日：2011-07-14

    申请人： CADILA HEALTHCARE LIMITED

    发明人： Rupal Joshi ,  Anita Nair ,  Anita Ramrakhiani ,  Sanjeev Kumar Mendiratta ,  Umang Trivedi

    IPC分类号： C12P17/18 ,  C12N9/04 ,  C12N9/02

    CPC分类号： C12P17/182 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/0008 ,  C12P17/12 ,  C12P41/002 ,  C12R1/19 ,  C12Y101/01047 ,  Y02P20/52

    摘要： The present invention provides a process for production of optically pure quinuclidinol of formula-(I) by reduction of quinuclidinone of formula-(II) in presence of suitable oxidoreductase enzyme derived from Saccharomyces species. Formula (II, I) Moreover, the present enzyme works in presence of cofactor NADP where the cofactor is regenerated by suitable system. The present invention also provides a recombinant vector containing genes co expressing suitable polypeptides having oxido-reductase activity and polypeptide having capacity to regenerate the co-factor. The said vector is transformed in suitable host cell.

    摘要翻译： 本发明提供通过在衍生自酵母属物种的合适的氧化还原酶存在下还原式（II）的奎宁环酮来制备式 - （I）的光学纯奎宁环醇的方法。 式（II，I）此外，本发明酶在辅因子NADP的存在下起作用，其中辅因子通过合适的系统再生。 本发明还提供了含有表达具有氧化还原酶活性的合适多肽的基因的重组载体和具有再生辅助因子能力的多肽。 所述载体在合适的宿主细胞中转化。