发明申请
- 专利标题： COMPOSITIONS AND METHODS FOR LONG ACTING MOLECULES
- 专利标题（中）： 组合物和长期作用分子的方法
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申请号： US14109426申请日： 2013-12-17
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公开(公告)号： US20140186350A1公开(公告)日： 2014-07-03
- 发明人: Joy GHOSH , Michael ROGUSKA , Andrew Anh NGUYEN , Thomas PIETZONKA , Stephen POOR , Matthais MACHACEK , Chad BIGELOW
- 申请人： Joy GHOSH , Michael ROGUSKA , Andrew Anh NGUYEN , Thomas PIETZONKA , Stephen POOR , Matthais MACHACEK , Chad BIGELOW
- 申请人地址： DE BASEL
- 专利权人： NOVARTIS AG
- 当前专利权人： NOVARTIS AG
- 当前专利权人地址： DE BASEL
- 主分类号： A61K47/42
- IPC分类号： A61K47/42 ; A61K39/395
摘要：
The invention relates, in part, to compositions and methods that utilize a peptide tag that binds to hemagglutanin (HA). The HA tag can be linked to a molecule such as a protein or nucleic acid which, when administered to the eye, results in an increase in ocular half-life and/or mean residence time, and or a decrease in ocular clearance of the protein or nucleic acid. The invention also encompasses methods for treating ocular disease, including retinal vascular disease, by administering a protein or nucleic acid linked to an HA peptide tag.