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公开(公告)号：US20230137084A1
公开(公告)日：2023-05-04
申请号：US17973640
申请日：2022-10-26
发明人： Christina H. Drake
IPC分类号： A61K9/14 , A61K33/38 , A61K33/34 , A61K33/30 , A61K33/26 , A61K33/242 , A61K33/243 , A61K33/24 , A61K33/00 , A61K47/36 , A61K47/10 , A61K47/42 , A61K47/34 , A61K38/19 , A61P27/02
摘要： A wound healing composition is provided that includes a tissue adhesive or epithelial tissue healing agent and metal-modified cerium oxide nanoparticles (mCNPs). The nCNPs have a predominant 3+ surface charge and are in a range of about 3-35 nanometers (nm) in size and mixed in an amount that is in a range of about 0.01 to 0.1 weight percentage of a mixture having the tissue adhesive or epithelial tissue healing agent and the mCNPs. The metal (m) is a stable metallic metal with antimicrobial properties and non-ionizing. The mCNPs includes AgCNP2. A method is provided that uses the healing composition to treat a wound or epithelial tissue. The composition can be used to treat the skin or eye and/or subcutaneous tissue.
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公开(公告)号：US11633374B2
公开(公告)日：2023-04-25
申请号：US17850050
申请日：2022-06-27
IPC分类号： A61K31/25 , A61K31/235 , A61K31/7008 , A61K31/047 , A61K9/14 , A61K38/00 , A61K9/08 , A61K47/34 , A61K47/10 , A61J1/06 , A61J7/00 , A61K9/00 , A61K47/69 , A61P25/00 , A61K9/48 , A61K47/20 , A61K47/26 , A61K47/36 , A61K47/42
摘要： Compositions are provided for the liquid oral administration of topiramate and its salts. The invention further provides methods for treating diseases and disorders using the compositions.
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公开(公告)号：US20230065872A1
公开(公告)日：2023-03-02
申请号：US17831645
申请日：2022-06-03
发明人： David S. Soane , Philip Wuthrich , Robert P. Mahoney , Mark Moody , Daniel G. Greene , Neil L. Schauer
IPC分类号： A61K47/22 , A61K39/395 , A61K47/18 , A61K9/00 , A61K47/12 , A61K47/60 , A61K47/24 , A61K47/20 , C07K16/00 , A61K47/42 , A61K38/38 , A61K38/47 , C12N9/36 , C12N9/96 , A61K38/19 , A61K38/17 , A61K47/02 , A61K38/18 , C07K16/22 , C07K16/32
摘要： Disclosed herein are methods for improving a parameter of a protein-related process comprising providing a viscosity-reducing excipient compound selected from the group consisting of hindered amines, anionic aromatics, functionalized amino acids, oligopeptides, short-chain organic acids, and low molecular weight aliphatic polyacids, and adding a viscosity-reducing amount of the viscosity-reducing excipient compound to a carrier solution for the protein-related process, wherein the carrier solution contains a protein of interest, and carrier solutions comprising a liquid medium in which is dissolved a protein of interest, and a viscosity-reducing excipient, wherein the viscosity of the carrier solution has a lower viscosity that that of a control solution that is substantially similar to the carrier solution except for the presence of the viscosity-reducing excipient.
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公开(公告)号：US20230063104A1
公开(公告)日：2023-03-02
申请号：US17759926
申请日：2021-02-04
申请人： HIERABIO INC
发明人： Seung Jin LEE , Heejung KIM , Ji Young SHIN , Jeong Hwa JEON
摘要： The present invention relates to a composition for intrapericardial injection comprising stem cells, and a use thereof, and more particularly, to a composition for improving the therapeutic effect of stem cells by effective transplantation of the stem cells into the pericardium.
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公开(公告)号：US11590076B2
公开(公告)日：2023-02-28
申请号：US16954324
申请日：2018-12-14
IPC分类号： A61K9/06 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K31/7068 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61K47/46 , C07K16/28
摘要： The present invention relates to a cryogel scaffold capable of controlling the degree of degradation and a soft bio-integrated device in which a drug modulating an immunosuppressive action in solid tumor microenvironment is loaded in the scaffold.
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公开(公告)号：US11583584B1
公开(公告)日：2023-02-21
申请号：US15337845
申请日：2016-10-28
发明人： Jun Liu , Mark Manning , Isaias Prado
IPC分类号： A61K39/395 , A61K9/00 , A61K47/40 , A61K47/42 , A61K47/18 , A61K47/34 , A61K47/02 , A61K47/12
摘要： The present invention is directed to compositions and methods for stabilizing a protein without a surfactant. The present invention is further directed to compositions comprising a protein and at least one excipient selected from the group consisting of hindered amines, anionic aromatics, functionalized amino acids, oligopeptides, low molecular weight aliphatic polyacids, zwitterions, phospholipids, cyclodextrins, polyethylene glycols, gelatins, urea, ethanol, glycerin, dextran, xanthan gum, 2-(2-ethoxyethoxy)ethanol, hydroxypropyl cellulose, propylene glycol, a short-chain organic acid, deoxycholate, sodium nitrate, sodium sulfate, proline and lysine.
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7.发明申请公开(公告)号：US20230041441A1
公开(公告)日：2023-02-09
申请号：US17935864
申请日：2022-09-27
发明人： Richard J. Porambo , Chitrananda Abeygunawardana , Luwy Kavuka Musey , Michael J. Kosinski , Yadong Adam Cui , Julie Marie Skinner
摘要： The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Streptococcus pneumoniae serotypes.
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公开(公告)号：US11571407B2
公开(公告)日：2023-02-07
申请号：US15102358
申请日：2014-12-19
申请人： BCN PEPTIDES, S.A.
发明人： Josep Farrera-Sinfreu , Leslie Matalonga Borrel , Laura Gort Mas , Roberto Pascual Martínez , Antonio Ferrer Montiel , Antonia Ribes Rubió , Berta Ponsati Obiols
IPC分类号： A61K31/277 , A61K31/167 , A61K47/42 , G01N33/566
摘要： The invention provides a therapy for lysosomal storage diseases and glycogenosis by treatment with compounds that promote exocytosis, preferably lysosomal exocytosis. The treatment of cells from patients affected by different lysosomal storage disorders with exocytosis activating compounds leads to a decrease in the accumulation of toxic substrate in the lysosomes, thus allowing the treatment, prevention and relief of the symptoms of many lysosomal storage disorders.
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公开(公告)号：US20230035013A1
公开(公告)日：2023-02-02
申请号：US17757356
申请日：2020-12-23
IPC分类号： A61K35/36 , C12N5/0797 , A61K9/06 , A61K47/42 , A61K9/00
摘要： The invention pertains to an ophthalmological device (100, 200) for the treatment of Limbal Stem Cell Deficiency, the device (100, 200) comprising: a stem cell carrier substrate; and a culture of limbal epithelial stem cells cultivated on said stem cell carrier substrate; wherein said stem cell carrier substrate comprises a hydrogel containing collagen or collagen-mimicking peptides; and wherein a ring-shaped area on a surface of said stem cell carrier substrate is provided with a pattern of niches (110, 210). The invention also pertains to a method for producing the ophthalmological device.
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公开(公告)号：US20230027396A1
公开(公告)日：2023-01-26
申请号：US17825027
申请日：2022-05-26
发明人： David S. Soane , Philip Wuthrich , Robert P. Mahoney , Yuhong Zeng , Subhashchandra Naik , Timothy Tran
IPC分类号： A61K47/22 , A61K47/60 , A61K9/00 , A61K38/38 , A61K38/47 , C12N9/36 , C12N9/96 , C07K16/00 , A61K39/395 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/24 , A61K47/42
摘要： Disclosed herein are reduced viscosity liquid formulations comprising a protein and an excipient compounds. Further disclosed are methods of reducing the viscosity of a liquid formulation comprising a protein, methods of treatment, and methods of improving protein processing.
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