发明申请
- 专利标题： Methods of preparing antibody-active agent conjugates
- 专利标题（中）： 制备抗体活性剂缀合物的方法
-
申请号： US14181649申请日： 2014-02-15
-
公开(公告)号： US20140187756A1公开(公告)日： 2014-07-03
- 发明人: Yongzu Kim , Taekyo Park , Sungho Woo , Hyangsook Lee , Sunyoung Kim , Jongun Cho , Doohwan Jung , Youngun Kim , Hyunjin Kwon , Kyuman Oh , Yunseo Chung , Yun-Hee Park
- 申请人： LegoChem Biosciences, Inc.
- 申请人地址： KR Daejeon
- 专利权人： LegoChem Biosciences, Inc.
- 当前专利权人： LegoChem Biosciences, Inc.
- 当前专利权人地址： KR Daejeon
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K47/48
摘要：
The invention provides methods for preparing an antibody-active agent conjugate. The conjugate comprises an antibody, a cysteine residue of an amino acid motif that can be recognized by an isoprenoid transferase located at or after the carboxy-terminus of the antibody, an isoprenoid unit operably linked to the cysteine residue, and an active agent. The invention also provides a composition comprising the antibody-active agent conjugate prepared by the methods.
信息查询
