-
公开(公告)号：US20140161829A1
公开(公告)日：2014-06-12
申请号：US14181648
申请日：2014-02-15
发明人： Yongzu Kim , Taekyo Park , Sungho Woo , Hyangsook Lee , Sunyoung Kim , Jongun Cho , Doohwan Jung , Youngun Kim , Hyunjin Kwon , Kyuman Oh , Yunseo Chung , Yun-Hee Park
IPC分类号： A61K47/48
CPC分类号： A61K47/6811 , A61K47/549 , A61K47/55 , A61K47/65 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6859 , A61K47/6889 , C07K16/2863 , C07K16/32 , C12Q1/48
摘要： The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).
摘要翻译： 本发明提供了具有可被类异戊二烯转移酶识别的氨基酸基序的蛋白质 - 活性剂缀合物。 本发明还提供含有缀合物的组合物。 本发明还提供了使用结合物将活性剂递送至靶细胞的方法，以及使用缀合物治疗有此需要的受试者（例如需要活性剂的受试者）的方法。
-
公开(公告)号：US10583197B2
公开(公告)日：2020-03-10
申请号：US15612766
申请日：2017-06-02
发明人： Yongzu Kim , Taekyo Park , Sungho Woo , Hyangsook Lee , Sunyoung Kim , Jongun Cho , Doohwan Jung , Youngun Kim , Hyunjin Kwon , Kyuman Oh , Yunseo Chung , Yun-Hee Park
摘要： The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).
-
公开(公告)号：US20150105541A1
公开(公告)日：2015-04-16
申请号：US14517616
申请日：2014-10-17
发明人： Yongzu Kim , Taekyo Park , Sungho Woo , Hyangsook Lee , Sunyoung Kim , Jongun Cho , Doohwan Jung , Youngun Kim , Hyunjin Kwon , Kyuman Oh , Yunseo Chung , Yun-Hee Park
IPC分类号： A61K47/48
CPC分类号： A61K47/6811 , A61K47/549 , A61K47/55 , A61K47/65 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6859 , A61K47/6889 , C07K16/2863 , C07K16/32 , C12Q1/48
摘要： The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent)
摘要翻译： 本发明提供了具有可被类异戊二烯转移酶识别的氨基酸基序的蛋白质 - 活性剂缀合物。 本发明还提供含有缀合物的组合物。 本发明还提供了使用结合物将活性剂递送至靶细胞的方法，以及使用缀合物治疗有需要的受试者（例如，需要活性剂的受试者）的方法，
-
公开(公告)号：US20140187756A1
公开(公告)日：2014-07-03
申请号：US14181649
申请日：2014-02-15
发明人： Yongzu Kim , Taekyo Park , Sungho Woo , Hyangsook Lee , Sunyoung Kim , Jongun Cho , Doohwan Jung , Youngun Kim , Hyunjin Kwon , Kyuman Oh , Yunseo Chung , Yun-Hee Park
CPC分类号： A61K47/6811 , A61K47/549 , A61K47/55 , A61K47/65 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6859 , A61K47/6889 , C07K16/2863 , C07K16/32 , C12Q1/48
摘要： The invention provides methods for preparing an antibody-active agent conjugate. The conjugate comprises an antibody, a cysteine residue of an amino acid motif that can be recognized by an isoprenoid transferase located at or after the carboxy-terminus of the antibody, an isoprenoid unit operably linked to the cysteine residue, and an active agent. The invention also provides a composition comprising the antibody-active agent conjugate prepared by the methods.
摘要翻译： 本发明提供了制备抗体 - 活性剂缀合物的方法。 缀合物包含抗体，氨基酸基序的半胱氨酸残基，其可被位于抗体的羧基末端或之后的类异戊二烯转移酶识别，与半胱氨酸残基可操作地连接的类异戊二烯单元和活性剂。 本发明还提供包含通过该方法制备的抗体 - 活性剂缀合物的组合物。
-
公开(公告)号：US20200289662A1
公开(公告)日：2020-09-17
申请号：US16812690
申请日：2020-03-09
发明人： YongZu Kim , Taekyo Park , Sungho Woo , Hyangsook Lee , Sunyoung Kim , Jongun Cho , Doohwan Jung , Youngun Kim , Hyunjin Kwon , Kyuman Oh , Yunseo Chung , Yun-Hee Park
摘要： The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent)
-
公开(公告)号：US09669107B2
公开(公告)日：2017-06-06
申请号：US14517616
申请日：2014-10-17
发明人： Yongzu Kim , Taekyo Park , Sungho Woo , Hyangsook Lee , Sunyoung Kim , Jongun Cho , Doohwan Jung , Youngun Kim , Hyunjin Kwon , Kyuman Oh , Yunseo Chung , Yun-Hee Park
CPC分类号： A61K47/6811 , A61K47/549 , A61K47/55 , A61K47/65 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6859 , A61K47/6889 , C07K16/2863 , C07K16/32 , C12Q1/48
摘要： The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.018 秒)
