The present invention relates to a convenient, minimally invasive surgical instrument, and more particularly to a minimally invasive surgical instrument to allow a user to operate an end effector by manipulating a handling unit or the like to perform a minimally invasive surgery in a delicate and convenient manner. According to one aspect of the invention, there is provided a minimally invasive surgical instrument comprising: a shaft; an end effector being connected to one end of the shaft via a joint unit; a rotation manipulation unit being connected to to the other end of the shaft, the rotation manipulation unit comprising a gyro link including a gyro wheel; and a plurality of wires being connected between the joint unit and the gyro wheel, wherein the end effector carries out joint motion by the joint unit according to the action of at least some of the plurality of wires caused by a manipulation of the gyro wheel.