发明申请
US20140219961A1 PHARMACEUTICAL COMPOSITION FOR TREATING CANCER, COMPRISING INTERFERON ALPHA CONJUGATE
有权
用于治疗癌症的药物组合物,包括干扰素ALPHA联合
- 专利标题: PHARMACEUTICAL COMPOSITION FOR TREATING CANCER, COMPRISING INTERFERON ALPHA CONJUGATE
- 专利标题(中): 用于治疗癌症的药物组合物,包括干扰素ALPHA联合
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申请号: US14342715申请日: 2012-09-05
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公开(公告)号: US20140219961A1公开(公告)日: 2014-08-07
- 发明人: Sung Youb Jung , Young Eun Woo , Se Young Lim , In Young Choi , Jae Ho Lee , Se Chang Kwon , Sung Hwan Moon , Jiawang Liu
- 申请人: Sung Youb Jung , Young Eun Woo , Se Young Lim , In Young Choi , Jae Ho Lee , Se Chang Kwon , Sung Hwan Moon , Jiawang Liu
- 申请人地址: CN Beijing KR Hwaseong-si, Gyeonggi-do
- 专利权人: BEIJING HANMI PHARMACEUTICAL CO., LTD.,HANMI SCIENCE CO., LTD.
- 当前专利权人: BEIJING HANMI PHARMACEUTICAL CO., LTD.,HANMI SCIENCE CO., LTD.
- 当前专利权人地址: CN Beijing KR Hwaseong-si, Gyeonggi-do
- 优先权: CN201110269277.0 20110905
- 国际申请: PCT/KR2012/007113 WO 20120905
- 主分类号: A61K47/48
- IPC分类号: A61K47/48 ; A61K31/7068 ; A61K38/21
摘要:
A method for preventing or treating a cancer includes administering an anti-cancer pharmaceutical composition including an interferon alpha or a polymer conjugate thereof. The pharmaceutical composition can be co-administered with anti-cancer agents. The interferon alpha conjugate shows a longer in vivo half-life and a more excellent anti-cancer activity than the conventional interferon alpha, and in particular, its co-administration with an anti-cancer agent such as gemcitabine has synergistic inhibitory effects on cancer cell growth and proliferation so as to exhibit a remarkably excellent anti-cancer activity. Further, the anti-cancer pharmaceutical composition has excellent in vivo half-life and anti-cancer activity to greatly reduce administration frequency. Co-administration of an anti-cancer agent and the interferon alpha conjugate having excellent anti-cancer activity reduces administration dose of anti-cancer agent so as to reduce side effects of anti-cancer agent and increase treatment compliance of patient.
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