发明申请
US20140248684A1 COMPOSITIONS AND METHODS FOR THE PRODUCTION AND USE OF HUMAN CHOLINESTERASES
审中-公开
用于生产和使用人类胆固醇的组合物和方法
- 专利标题： COMPOSITIONS AND METHODS FOR THE PRODUCTION AND USE OF HUMAN CHOLINESTERASES
- 专利标题（中）： 用于生产和使用人类胆固醇的组合物和方法
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申请号： US14344974申请日： 2012-09-17
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公开(公告)号： US20140248684A1公开(公告)日： 2014-09-04
- 发明人: Tsafrir Mor , Latha Kannan , Katherine E. Larrimore
- 申请人： Tsafrir Mor , Latha Kannan , Katherine E. Larrimore
- 申请人地址： US AZ Scottsdale
- 专利权人： ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY
- 当前专利权人： ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY
- 当前专利权人地址： US AZ Scottsdale
- 国际申请： PCT/US2012/055781 WO 20120917
- 主分类号： C12N9/18
- IPC分类号： C12N9/18 ; C12N15/82
摘要：
In some aspects, the present invention relates to compositions and methods for the production of human cholinesterases. More particularly, it relates to methods for the production of human cholinesterases using transient expression and vectors for producing the same. In one aspect, the present invention relates to a plant viral vector encoding a plant codon-optimized DNA sequence that results in accumulation of the cholinesterase in a plant leaf at levels greater than 20 mg, and in some embodiments greater than 200 mg, of the enzyme per kilogram of the plant leaf.
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