公开(公告)号：US11180765B2

公开(公告)日：2021-11-23

申请号：US16990033

申请日：2020-08-11

申请人： The Arizona Board of Regents for and on Behalf of Arizona State University ,  The Washington University

发明人： Roy Curtiss, III ,  Shifeng Wang ,  Soo-Young Wanda ,  Wei Kong

IPC分类号： C12Q1/68 ,  C12N15/74 ,  A61K35/74 ,  C12N1/36 ,  A61K39/00 ,  A61K35/00

摘要： The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.

公开(公告)号：US20180185477A1

公开(公告)日：2018-07-05

申请号：US15898780

申请日：2018-02-19

申请人： Yeda Research and Development Co. Ltd. ,  Arizona Board of Regents for and on behalf of Arizona State University

发明人： Douglas LAKE ,  Benjamin KATCHMAN ,  Deborah FASS

IPC分类号： A61K39/395

CPC分类号： A61K39/3955 ,  A61K38/44 ,  A61K39/39558 ,  A61K2121/00 ,  C07K16/40 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/30 ,  C12Q1/26 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Y108/03002 ,  G01N33/5008 ,  G01N33/5011

摘要： The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.

公开(公告)号：US09933825B2

公开(公告)日：2018-04-03

申请号：US14207859

申请日：2014-03-13

申请人： Arizona Board of Regents for and on behalf of Arizona State University

发明人： Vinay Hanumaiah ,  Sarma Vrudhula

IPC分类号： G06F1/26 ,  G06F1/32 ,  G06F1/20

CPC分类号： G06F1/206 ,  G06F1/324 ,  G06F1/3296 ,  Y02D10/126 ,  Y02D10/16 ,  Y02D10/172

摘要： An example process for controlling a processor may include: (i) obtaining parameters associated with operation of a processor, where each of the parameters has a different time scale; (ii) performing an iterative process to identify ones of the parameters that achieve a particular energy efficiency in the processor, where the energy efficiency of the processor corresponds to a quasi-concave function having a maximum that corresponds to the ones of the parameters; and (iii) controlling the processor using the ones of the parameters.

公开(公告)号：US09751785B2

公开(公告)日：2017-09-05

申请号：US14509722

申请日：2014-10-08

申请人： Kyle Doudrick ,  Kiril D. Hristovski ,  Paul K. Westerhoff

发明人： Kyle Doudrick ,  Kiril D. Hristovski ,  Paul K. Westerhoff

IPC分类号： C02F1/30 ,  C02F1/32 ,  C02F1/44 ,  C02F1/70 ,  C02F1/00 ,  C02F101/16 ,  C02F101/22

CPC分类号： C02F1/70 ,  C02F1/008 ,  C02F1/30 ,  C02F1/32 ,  C02F1/444 ,  C02F2101/163 ,  C02F2101/22 ,  C02F2209/003 ,  C02F2209/005 ,  C02F2209/02 ,  C02F2209/06 ,  C02F2209/15 ,  C02F2209/22 ,  C02F2209/40 ,  C02F2305/10 ,  Y02W10/37

摘要： A water treatment system including: a flow regulation control system configured to combine oxo-anion-contaminated water with a reduction-promoting agent, a hole scavenger, or both; a reactor fluidically coupled to the flow regulation control system; a first set of system control probes configured to monitor the concentration of oxygen and oxo-anion in the contaminated water; a second set of system control probes configured to monitor concentration of the oxo-anion and reduction products of the oxo-anion in treated effluent from the reactor; and a controller configured to control the flow regulation control system, thereby controlling the flow rate of the contaminated water and the at least one of the reduction-promoting agent and the hole scavenger to the reactor based at least in part on the concentration of oxo-anion and the reduction products of the oxo-anion in the treated effluent.

公开(公告)号：US09598697B2

公开(公告)日：2017-03-21

申请号：US13700591

申请日：2011-05-31

申请人： Roy Curtiss, III ,  Wei Kong

发明人： Roy Curtiss, III ,  Wei Kong

IPC分类号： A01N63/00 ,  C12N1/20 ,  C12N15/74 ,  C12R1/42 ,  A61K35/74 ,  C12N1/36

CPC分类号： C12N15/74 ,  A61K35/74 ,  C12N1/36 ,  C12R1/42

摘要： A recombinant bacterium capable of reducing tumor growth is provided, wherein said recombinant bacterium is capable of: a. increased expression of a nucleic acid encoding a chemoreceptor that directs chemotaxis towards tumors, b. accumulation in a quiescent tumor, c. hyper-invasion of a tumor, d. reduced fitness in normal tissue, e. enhanced stimulation of the host innate immune responses, f. delivering a tumor specific DNA vaccine vector to a tumor cell, and g. increased bacterium-induced host programmed cell death.

公开(公告)号：US09297015B2

公开(公告)日：2016-03-29

申请号：US13789665

申请日：2013-03-07

申请人： Roy Curtiss, III ,  Shifeng Wang ,  Soo-Young Wanda ,  Wei Kong

发明人： Roy Curtiss, III ,  Shifeng Wang ,  Soo-Young Wanda ,  Wei Kong

IPC分类号： A61K35/74 ,  C12N15/74 ,  C12N1/36 ,  A61K39/00

CPC分类号： C12N15/74 ,  A61K35/74 ,  A61K39/00 ,  A61K2035/11 ,  A61K2039/522 ,  A61K2039/523 ,  C12N1/36

摘要： The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.

公开(公告)号：US09255283B2

公开(公告)日：2016-02-09

申请号：US13805733

申请日：2011-07-01

申请人： Roy Curtiss, III ,  Xinyao Liu

发明人： Roy Curtiss, III ,  Xinyao Liu

IPC分类号： C12P7/64 ,  C07K14/195 ,  C12N9/18 ,  C12N9/20 ,  C12N9/36

CPC分类号： C12P7/6463 ,  C07K14/195 ,  C12N9/18 ,  C12N9/20 ,  C12N9/2462

摘要： The present invention is directed to a cyanobacterium that produces neutral lipids or alkanes. Such neutral lipids or alkanes may be used for biofuel production.

摘要翻译： 本发明涉及产生中性脂质或烷烃的蓝细菌。 这种中性脂质或烷烃可用于生产生物燃料。

公开(公告)号：US20150349775A1

公开(公告)日：2015-12-03

申请号：US12776188

申请日：2010-05-07

申请人： Lawrence T. Clark ,  Kyle E. Nielsen

发明人： Lawrence T. Clark ,  Kyle E. Nielsen

IPC分类号： H03K19/003 ,  H01L27/088 ,  H01L27/092 ,  H01L27/06 ,  H03K19/20 ,  H01L23/50 ,  H03K3/037 ,  H03K19/0175 ,  H03K19/00 ,  H01L27/02 ,  H01L23/00

CPC分类号： H03K19/23 ,  H01L23/50 ,  H01L24/03 ,  H01L24/05 ,  H01L27/0255 ,  H01L27/0629 ,  H01L27/088 ,  H01L27/092 ,  H01L2224/0401 ,  H01L2224/04042 ,  H01L2924/14 ,  H01L2924/1426 ,  H03K3/0377 ,  H03K19/0002 ,  H03K19/00338 ,  H03K19/00392 ,  H03K19/017509 ,  H03K19/20

摘要： Embodiments of radiation hardened by design digital input/output circuits are described herein. Other examples and related methods are also disclosed herein.

摘要翻译： 本文描述了由设计数字输入/输出电路硬化的辐射的实施例。 本文还公开了其它实例和相关方法。

公开(公告)号：US09184478B2

公开(公告)日：2015-11-10

申请号：US13105794

申请日：2011-05-11

申请人： Cody A. Friesen ,  Daniel Buttry

发明人： Cody A. Friesen ,  Daniel Buttry

IPC分类号： H01M12/08 ,  H01M4/90 ,  H01M12/06 ,  H01M4/86

CPC分类号： H01M8/02 ,  H01M4/86 ,  H01M4/90 ,  H01M12/06 ,  H01M12/08 ,  H01M2300/0022 ,  H01M2300/0025 ,  H01M2300/0045 ,  Y02E60/128

摘要： Systems and methods drawn to an electrochemical cell comprising a low temperature ionic liquid comprising positive ions and negative ions and a performance enhancing additive added to the low temperature ionic liquid. The additive dissolves in the ionic liquid to form cations, which are coordinated with one or more negative ions forming ion complexes. The electrochemical cell also includes an air electrode configured to absorb and reduce oxygen. The ion complexes improve oxygen reduction thermodynamics and/or kinetics relative to the ionic liquid without the additive.

摘要翻译： 绘制到电化学电池的系统和方法包括包含正离子和负离子的低温离子液体和添加到低温离子液体中的性能增强添加剂。 添加剂溶解在离子液体中以形成阳离子，其与一个或多个形成离子络合物的负离子配位。 电化学电池还包括构造成吸收和还原氧气的空气电极。 离子络合物相对于没有添加剂的离子液体改善氧还原热力学和/或动力学。

公开(公告)号：US09040059B2

公开(公告)日：2015-05-26

申请号：US12681711

申请日：2008-10-06

申请人： Roy Curtiss, III ,  Bereket Zekarias ,  Kenneth Roland

发明人： Roy Curtiss, III ,  Bereket Zekarias ,  Kenneth Roland

IPC分类号： A61K39/112 ,  A61K39/02 ,  A01N63/00 ,  A61K39/00 ,  C12N15/74

CPC分类号： A61K39/0275 ,  A61K39/025 ,  A61K2039/522 ,  A61K2039/523 ,  C12N15/74 ,  Y02A50/47 ,  Y02A50/482 ,  Y02A50/484

摘要： The present invention encompasses recombinant bacteria and immunogenic compositions comprising the bacteria. The immunogenic composition may be used to induce an immune response against C. perfringens.

摘要翻译： 本发明包括重组细菌和包含细菌的免疫原性组合物。 免疫原性组合物可用于诱导针对产气荚膜梭菌的免疫应答。