发明申请
US20140275083A1 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
审中-公开
3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES作为突变体IDH的抑制剂
- 专利标题： 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
- 专利标题（中）： 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES作为突变体IDH的抑制剂
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申请号： US14208015申请日： 2014-03-13
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公开(公告)号： US20140275083A1公开(公告)日： 2014-09-18
- 发明人: Thomas Raymond CAFERRO , Zhuoliang CHEN , Young Shin CHO , Abran Q. COSTALES , Julian Roy LEVELL , Gang LIU , James R. MANNING , Martin SENDZIK , Cynthia SHAFER , Michael David SHULTZ , James SUTTON , Yaping WANG , Qian ZHAO
- 申请人： Thomas Raymond CAFERRO , Zhuoliang CHEN , Young Shin CHO , Abran Q. COSTALES , Julian Roy LEVELL , Gang LIU , James R. MANNING , Martin SENDZIK , Cynthia SHAFER , Michael David SHULTZ , James SUTTON , Yaping WANG , Qian ZHAO
- 申请人地址： CH Basel
- 专利权人： NOVARTIS AG
- 当前专利权人： NOVARTIS AG
- 当前专利权人地址： CH Basel
- 主分类号： C07D413/04
- IPC分类号： C07D413/04 ; A61K31/5377 ; C07D417/14 ; C07D413/14 ; A61K31/506
摘要：
The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
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