公开(公告)号：US20140065141A1

公开(公告)日：2014-03-06

申请号：US14114878

申请日：2012-05-04

Applicant: Dylan Daniel ,  Johanna Joyce ,  James Sutton

Inventor： Dylan Daniel ,  Johanna Joyce ,  James Sutton

IPC: A61K31/4439 ,  A61K45/06 ,  A61K31/175 ,  A61K31/675 ,  A61K39/395 ,  A61K31/4545

CPC classification number: A61K31/4439 ,  A61K31/175 ,  A61K31/4545 ,  A61K31/675 ,  A61K39/3955 ,  A61K45/06 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention provides a compound of formula I; wherein R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl; or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. The invention also provides a method to treat a subject having a brain tumor such as glioblastoma, wherein the method comprises administering to the subject an effective amount of a compound of Formula I. Gene signatures correlated with successful treatment using these methods are also disclosed.

Abstract translation: 本发明提供式I化合物; 其中R1是烷基吡唑或烷基甲酰胺，R2是羟基环烷基; 或其药学上可接受的盐，以及含有这些化合物的组合物，用于治疗脑肿瘤，特别是成胶质细胞瘤。 本发明提供对脑肿瘤的有效治疗，并且可以通过口服施用本文进一步描述的式I化合物来使用。 本发明还提供了治疗具有脑肿瘤如胶质母细胞瘤的受试者的方法，其中所述方法包括给予受试者有效量的式I化合物。还公开了使用这些方法与成功治疗相关的基因标记。

公开(公告)号：US20120165306A1

公开(公告)日：2012-06-28

申请号：US13393457

申请日：2010-09-02

Applicant: Paul A. Barsanti ,  Cheng Hu ,  Cheng Hu ,  Keith B. Pfister ,  Martin Sendzik ,  James Sutton

Inventor： Paul A. Barsanti ,  Cheng Hu ,  Cheng Hu ,  Keith B. Pfister ,  Martin Sendzik ,  James Sutton

IPC: A61K31/497 ,  C07D405/14 ,  C07D413/14 ,  C07D409/14 ,  A61P31/18 ,  A61K31/553 ,  A61K31/55 ,  A61P35/00 ,  A61P29/00 ,  A61P9/00 ,  C07D401/14 ,  A61K31/5377

CPC classification number: C07D405/14 ,  C07D401/14

Abstract: The present invention provides a compound of Formula (I): and pharmaceutically acceptable salts thereof. Also provided is a method of using a compound of Formula I for treating a disease or condition mediated by a CDK inhibitor.

Abstract translation: 本发明提供式（I）的化合物及其药学上可接受的盐。 还提供了使用式I化合物治疗由CDK抑制剂介导的疾病或病症的方法。

公开(公告)号：US07895816B2

公开(公告)日：2011-03-01

申请号：US12255114

申请日：2008-10-21

Applicant: James Sutton ,  Allan James

Inventor： James Sutton ,  Allan James

IPC: A01D75/00

CPC classification number: A01D41/1243 ,  A01D75/00

Abstract: An apparatus for combines for the collection of threshed material discharged from the combine and automatically dumping the collected material when a predetermined weight of material is accumulated. The apparatus includes a threshed material collector attached to the combine for rotation about a horizontal axis that is closer to a forward end of the collector than a rearward end of the collector. The collector includes a plurality of horizontally spaced tines extending in a rearward direction and position to collect material discharged from the combine. A counter weight is attached to the collector for controlling the amount of material collected before the collector rotates under the weight of the collected material to a dumping position where the collected material is removed from the collector.

Abstract translation: 一种组合装置，用于收集从组合体排出的脱落材料，并在堆积预定重量的材料时自动倾倒收集的材料。 该装置包括一个连接到组合体上的脱落的材料收集器，用于围绕收集器的靠近收集器的前端的水平轴旋转，而不是集流器的后端。 收集器包括沿向后方向延伸的多个水平间隔的齿并且用于收集从组合体排出的材料。 收集器上装有一个配重，用于控制在收集器收集器在收集的材料的重量下旋转之前收集的材料的量到收集的材料从收集器移除的倾倒位置。

公开(公告)号：US20080109655A1

公开(公告)日：2008-05-08

申请号：US12005455

申请日：2007-12-27

Applicant: John Wilson ,  Ioannis Schoinas ,  Mazin Yousif ,  Linda Rankin ,  David Grawrock ,  Robert Greiner ,  James Sutton ,  Kushagra Vaid ,  Willard Wiseman

Inventor： John Wilson ,  Ioannis Schoinas ,  Mazin Yousif ,  Linda Rankin ,  David Grawrock ,  Robert Greiner ,  James Sutton ,  Kushagra Vaid ,  Willard Wiseman

IPC: H04L9/00

CPC classification number: G06F21/575 ,  G06F21/44 ,  G06F21/445 ,  G06F21/50 ,  G06F21/606 ,  G06F21/64 ,  G06F21/71 ,  G06F2221/034

Abstract: In one embodiment of the present invention, a method includes verifying an initiating logical processor of a system; validating a trusted agent with the initiating logical processor if the initiating logical processor is verified; and launching the trusted agent on a plurality of processors of the system if the trusted agent is validated. After execution of such a trusted agent, a secure kernel may then be launched, in certain embodiments. The system may be a multiprocessor server system having a partially or fully connected topology with arbitrary point-to-point interconnects, for example.

Abstract translation: 在本发明的一个实施例中，一种方法包括验证系统的起始逻辑处理器; 如果启动逻辑处理器被验证，则使用起始逻辑处理器验证可信代理; 以及如果所述信任代理被验证，则在所述系统的多个处理器上启动所述可信代理。 在执行这样的可信代理之后，在某些实施例中可以启动安全内核。 该系统可以是例如具有任意点到点互连的部分或完全连接的拓扑的多处理器服务器系统。

公开(公告)号：US20060160622A1

公开(公告)日：2006-07-20

申请号：US11275082

申请日：2005-12-08

Applicant: Steven Lee ,  Craig Sylla ,  James Sutton ,  Faith LeBrun ,  Jerome Carpenter

Inventor： Steven Lee ,  Craig Sylla ,  James Sutton ,  Faith LeBrun ,  Jerome Carpenter

IPC: A63F13/00

CPC classification number: G07F17/323 ,  G07F17/3241

Abstract: Software is download to a gaming device as a background operation while the gaming application runs in the foreground. An authorization operation may be completed before the download operation to prevent unauthorized installation of software. New games, software updates, and advertising content can be downloaded to the gaming machine in a background operation.

Abstract translation: 当游戏应用程序在前台运行时，软件作为背景操作下载到游戏设备。 在下载操作之前可以完成授权操作，以防止未经授权的软件安装。 新游戏，软件更新和广告内容可以在背景操作中下载到游戏机。

公开(公告)号：US20060143311A1

公开(公告)日：2006-06-29

申请号：US11026314

申请日：2004-12-29

Applicant: Rajesh Madukkarumukumana ,  James Sutton ,  Ioannis Schoinas ,  Richard Uhlig

Inventor： Rajesh Madukkarumukumana ,  James Sutton ,  Ioannis Schoinas ,  Richard Uhlig

IPC: G06F3/00

CPC classification number: G06F13/28

Abstract: A method and apparatus is described herein for supporting direct memory accesses between peer I/O devices. It is determined whether a guest physical address (GPA) referenced by an access generated from an I/O device, is within a range of GPAs associated with local I/O devices based at least in part on a GPA base and a GPA window size. If the GPA is within the window, then the GPA is translated to an HPA based at least in part on a base HPA associated with a local device and then forwarded to that local device. However, if the GPA is not within the window, then the access is forwarded upstream.

Abstract translation: 这里描述了一种用于支持对等I / O设备之间的直接存储器访问的方法和装置。 确定由I / O设备产生的访问所引用的访客物理地址（GPA）是否至少部分地基于GPA基础和GPA窗口大小在与本地I / O设备相关联的GPA的范围内 。 如果GPA在窗口内，则GPA至少部分基于与本地设备关联的基本HPA转换为HPA，然后转发到该本地设备。 但是，如果GPA不在窗口内，那么访问将在上游转发。

公开(公告)号：US20060059285A1

公开(公告)日：2006-03-16

申请号：US10942351

申请日：2004-09-15

Applicant: Stephen Fischer ,  Douglas Moran ,  James Sutton

Inventor： Stephen Fischer ,  Douglas Moran ,  James Sutton

IPC: G06F13/372

CPC classification number: G06F13/26 ,  G06F21/74

Abstract: A method and system of deadlock free bus protection of memory and I/O resources during secure execution. A bus cycle initiates entry of a bus agent into a secure execution mode. The chipset records an identifier of the secure mode processor. Thereafter, the chipset intercedes if another bus agent attempts a security sensitive bus cycle before the secure mode processor exits the secure mode.

Abstract translation: 在安全执行期间，存储器和I / O资源的无死锁总线保护方法和系统。 总线周期启动总线代理进入安全执行模式。 芯片组记录安全模式处理器的标识符。 此后，如果另一个总线代理在安全模式处理器退出安全模式之前尝试安全敏感的总线周期，则芯片组进行中介。

公开(公告)号：US20060020785A1

公开(公告)日：2006-01-26

申请号：US10883264

申请日：2004-06-30

Applicant: David Grawrock ,  Willard Wiseman ,  James Sutton ,  Clifford Hall ,  Ned Smith

Inventor： David Grawrock ,  Willard Wiseman ,  James Sutton ,  Clifford Hall ,  Ned Smith

IPC: H04L9/00

CPC classification number: G06F21/84 ,  G06F21/57

Abstract: A system and method for secure distribution of a video card public key. The method provides for loading an authentication code module into a processor, authenticating the authentication code module, and executing the authentication code module. Executing the authentication module causes the authentication code module to assert a hardware indicator to access at least one address in a special protected page on a chipset. Receipt of the hardware indicator by the chipset causes a specific reference to be sent via a dedicated port to a circuit card to retrieve a public key from the circuit card.

Abstract translation: 一种用于安全分发视频卡公钥的系统和方法。 该方法提供将认证码模块加载到处理器中，认证认证码模块和执行认证码模块。 执行认证模块使认证码模块断言硬件指示符访问芯片组中特殊保护页面中的至少一个地址。 通过芯片组接收硬件指示符，将特定的参考信号通过专用端口发送到电路卡以从电路卡中取回公钥。

公开(公告)号：US20060015751A1

公开(公告)日：2006-01-19

申请号：US10891699

申请日：2004-07-14

Applicant: Ernie Brickell ,  Alberto Martinez ,  David Grawrock ,  James Sutton ,  Clifford Hall

Inventor： Ernie Brickell ,  Alberto Martinez ,  David Grawrock ,  James Sutton ,  Clifford Hall

IPC: G06F12/14

CPC classification number: G06F21/73

Abstract: Secure storage and retrieval of a unique value associated with a device to/from a memory of a processing system. In at least one embodiment, the device needs to be able to access the unique value across processing system resets, and the device does not have sufficient non-volatile storage to store the unique value itself. Instead, the unique value is stored in the processing system memory in such a way that the stored unique value does not create a unique identifier for the processing system or the device. A pseudo-randomly or randomly generated initialization vector may be used to vary an encrypted data structure used to store the unique value in the memory.

公开(公告)号：US20060013402A1

公开(公告)日：2006-01-19

申请号：US10892256

申请日：2004-07-14

Applicant: James Sutton ,  Ernie Brickell ,  Clifford Hall ,  David Grawrock

Inventor： James Sutton ,  Ernie Brickell ,  Clifford Hall ,  David Grawrock

IPC: H04L9/00

CPC classification number: H04L9/0844 ,  H04L2209/127

Abstract: Delivering a Direct Proof private key to a device installed in a client computer system in the field may be accomplished in a secure manner without requiring significant non-volatile storage in the device. A unique pseudo-random value is generated and stored in the device at manufacturing time. The pseudo-random value is used to generate a symmetric key for encrypting a data structure holding a Direct Proof private key and a private key digest associated with the device. The resulting encrypted data structure is stored on a protected on-liner server accessible by the client computer system. When the device is initialized on the client computer system, the system checks if a localized encrypted data structure is present in the system. If not, the system obtains the associated encrypted data structure from the protected on-line server using a secure protocol. The device decrypts the encrypted data structure using a symmetric key regenerated from its stored pseudo-random value to obtain the Direct Proof private key. If the private key is valid, it may be used for subsequent authentication processing by the device in the client computer system.

Abstract translation: 将直接证明私钥提供给安装在该领域中的客户端计算机系统中的设备可以以安全的方式来实现，而不需要设备中的显着的非易失性存储。 在制造时产生并存储在设备中的唯一伪随机值。 伪随机值用于生成用于加密持有Direct Proof私钥和与该设备相关联的私钥摘要的数据结构的对称密钥。 所得到的加密数据结构存储在由客户端计算机系统可访问的受保护的在线服务器上。 当在客户端计算机系统上初始化设备时，系统会检查系统中是否存在本地化的加密数据结构。 如果没有，系统将使用安全协议从受保护的在线服务器获取相关联的加密数据结构。 设备使用从其存储的伪随机值重新生成的对称密钥来解密加密数据结构，以获得直接证明私钥。 如果私钥有效，则其可以用于客户端计算机系统中的设备的后续认证处理。