发明申请
- 专利标题: Novel Gold-Platinum Based Bi-Metallic Nanocrystal Suspensions, Electrochemical Manufacturing Processes Therefor and Uses for the Same
- 专利标题(中): 新型金 - 铂基双金属纳米晶体悬浮液,其电化学制造工艺及其用途
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申请号: US14008931申请日: 2012-03-30
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公开(公告)号: US20140294963A1公开(公告)日: 2014-10-02
- 发明人: Adam R Dorfman , David A. Bryce , Maxwell A. Grace , D. Kyle Pierce , Mikhail Merzliatov , Mark G. Mortenson
- 申请人: Adam R Dorfman , David A. Bryce , Maxwell A. Grace , D. Kyle Pierce , Mikhail Merzliatov , Mark G. Mortenson
- 国际申请: PCT/US12/31654 WO 20120330
- 主分类号: A61K33/24
- IPC分类号: A61K33/24 ; C22C1/04 ; C22C5/02 ; C22C30/00 ; C22C5/04
摘要:
The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension. The invention further includes pharmaceutical compositions thereof and the use of the bi-metallic nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which metal-based therapy is already known, including, for example, for cancerous diseases or conditions.