公开(公告)号：US20140294963A1

公开(公告)日：2014-10-02

申请号：US14008931

申请日：2012-03-30

申请人： Adam R Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliatov ,  Mark G. Mortenson

发明人： Adam R Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliatov ,  Mark G. Mortenson

IPC分类号： A61K33/24 ,  C22C1/04 ,  C22C5/02 ,  C22C30/00 ,  C22C5/04

CPC分类号： A61K33/24 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1611 ,  B82Y5/00 ,  C22C1/0466 ,  C22C5/02 ,  C22C5/04 ,  C22C30/00

摘要： The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension. The invention further includes pharmaceutical compositions thereof and the use of the bi-metallic nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which metal-based therapy is already known, including, for example, for cancerous diseases or conditions.

摘要翻译： 本发明涉及具有纳米晶体表面的新型金 - 铂基双金属纳米晶体悬浮液，其基本上不含与用于纳米颗粒形成过程中的典型化学还原剂/稳定剂和/或原料相关的有机或其它杂质或膜。 具体地说，相对于使用需要有机（或其它）还原剂和/或表面活性剂从金属生长（和/或悬浮）金属纳米粒子的化学还原（和其它）方法制备的金属基纳米颗粒的表面，表面“干净” 离子在溶液中。 本发明包括用于制备双金属纳米晶体悬浮液的新型电化学制造装置和技术。 这些技术不需要使用或存在氯离子/原子和/或氯化物或氯基材料用于制造过程/最终悬浮液。 本发明还包括其药物组合物，以及双金属纳米晶体或其悬浮液或胶体在治疗或预防已知金属基治疗的疾病或病症中的用途，包括例如癌性疾病或病症 。

公开(公告)号：US20230172975A1

公开(公告)日：2023-06-08

申请号：US17708253

申请日：2022-03-30

申请人： Adam R. Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliakov ,  Mark G. Mortenson

发明人： Adam R. Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliakov ,  Mark G. Mortenson

IPC分类号： A61K33/243 ,  A61K9/14 ,  A61K9/10 ,  A61K33/242 ,  C22C1/04 ,  C22C5/02 ,  C22C5/04 ,  C22C30/00 ,  A61K9/16

CPC分类号： A61K33/243 ,  A61K9/14 ,  A61K9/10 ,  A61K33/242 ,  C22C1/0466 ,  C22C5/02 ,  C22C5/04 ,  C22C30/00 ,  A61K9/1611 ,  B82Y5/00

摘要： The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution.
The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension. The invention further includes pharmaceutical compositions thereof and the use of the bi-metallic nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which metal-based therapy is already known, including, for example, for cancerous diseases or conditions.

公开(公告)号：US09387225B2

公开(公告)日：2016-07-12

申请号：US14008931

申请日：2012-03-30

申请人： Adam R. Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliakov ,  Mark G. Mortenson

发明人： Adam R. Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliakov ,  Mark G. Mortenson

IPC分类号： A61K33/24 ,  A61K9/14 ,  C22C1/04 ,  C22C5/02 ,  C22C5/04 ,  C22C30/00 ,  A61K9/10

CPC分类号： A61K33/24 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1611 ,  B82Y5/00 ,  C22C1/0466 ,  C22C5/02 ,  C22C5/04 ,  C22C30/00

摘要： The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension. The invention further includes pharmaceutical compositions thereof and the use of the bi-metallic nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which metal-based therapy is already known, including, for example, for cancerous diseases or conditions.

摘要翻译： 本发明涉及具有纳米晶体表面的新型金 - 铂基双金属纳米晶体悬浮液，其基本上不含与用于纳米颗粒形成过程中的典型化学还原剂/稳定剂和/或原料相关的有机或其它杂质或膜。 具体地说，相对于使用需要有机（或其它）还原剂和/或表面活性剂从金属生长（和/或悬浮）金属纳米粒子的化学还原（和其它）方法制备的金属基纳米颗粒的表面，表面“干净” 离子在溶液中。 本发明包括用于制备双金属纳米晶体悬浮液的新型电化学制造装置和技术。 这些技术不需要使用或存在氯离子/原子和/或氯化物或氯基材料用于制造过程/最终悬浮液。 本发明还包括其药物组合物，以及双金属纳米晶体或其悬浮液或胶体在治疗或预防金属基治疗已知的疾病或病症中的应用，包括例如癌性疾病或病症 。

公开(公告)号：US20160317578A1

公开(公告)日：2016-11-03

申请号：US15204534

申请日：2016-07-07

申请人： Adam R. Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliakov ,  Mark G. Mortenson

发明人： Adam R. Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliakov ,  Mark G. Mortenson

IPC分类号： A61K33/24 ,  A61K9/16

CPC分类号： A61K33/24 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1611 ,  B82Y5/00 ,  C22C1/0466 ,  C22C5/02 ,  C22C5/04 ,  C22C30/00

摘要： The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution.The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension. The invention further includes pharmaceutical compositions thereof and the use of the bi-metallic nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which metal-based therapy is already known, including, for example, for cancerous diseases or conditions.

摘要翻译： 本发明包括用于制备双金属纳米晶体悬浮液的新型电化学制造装置和技术。 这些技术不需要使用或存在氯离子/原子和/或氯化物或氯基材料用于制造过程/最终悬浮液。 本发明还包括其药物组合物，以及双金属纳米晶体或其悬浮液或胶体在治疗或预防金属基治疗已知的疾病或病症中的应用，包括例如癌性疾病或病症 。

公开(公告)号：US20160375058A1

公开(公告)日：2016-12-29

申请号：US15199009

申请日：2016-06-30

申请人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

发明人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

IPC分类号： A61K33/30 ,  A61K9/51 ,  B01J19/08 ,  A61K33/38

CPC分类号： A61K33/30 ,  A61K9/5192 ,  A61K33/38 ,  B01J19/088 ,  B01J2219/0809 ,  B01J2219/0813 ,  B01J2219/0816 ,  B01J2219/082 ,  B01J2219/0822 ,  B01J2219/083 ,  B01J2219/0841 ,  B01J2219/0869 ,  B01J2219/0877 ,  B01J2219/0896

摘要： This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, zeta potential and properties present in a liquid.

公开(公告)号：US08617360B2

公开(公告)日：2013-12-31

申请号：US12668181

申请日：2008-07-11

申请人： David K. Pierce ,  Mark G. Mortenson ,  David A. Bryce

发明人： David K. Pierce ,  Mark G. Mortenson ,  David A. Bryce

IPC分类号： H05F3/00 ,  C25C1/22 ,  C25C1/20 ,  H05F3/06 ,  H05F3/02 ,  H05F3/04

CPC分类号： A01N59/16 ,  A01N59/00 ,  B01J19/088 ,  B01J2219/0811 ,  B01J2219/0894 ,  B22F3/003 ,  B22F2999/00 ,  C22B3/02 ,  C22B3/22 ,  C22B4/005 ,  C22B4/08 ,  H05H1/48 ,  H05H2001/483 ,  Y02P10/234 ,  B22F9/14 ,  B22F2202/13 ,  B22F1/0018 ,  C25C5/02

摘要： Methods and devices for the continuous manufacture of nanop∈rticles, microparticles and nanoparticle/liquid solution(s) are disclosed. The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e. g., created) in a liquid (e.g., water) by utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s).

摘要翻译： 公开了用于连续制造纳米颗粒，微粒和纳米颗粒/液体溶液的方法和装置。 纳米颗粒（和/或微米尺寸的颗粒）包含各种可能的组合物，尺寸和形状。 通过利用至少一个可调等离子体（例如，由至少一个AC和/或DC电源产生），使颗粒（例如，纳米颗粒）存在（例如，产生）在液体（例如，水）中，其中 等离子体与液体的至少一部分表面连通。 连续过程使至少一种液体流入，通过和流出至少一个槽构件，这种液体在所述槽构件中被处理，调节和/或实现。

公开(公告)号：US08540942B2

公开(公告)日：2013-09-24

申请号：US12686815

申请日：2010-01-13

申请人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

发明人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

IPC分类号： B01J19/08

CPC分类号： H05H1/48 ,  B01J19/088 ,  B01J2219/0004 ,  B01J2219/0809 ,  B01J2219/0813 ,  B01J2219/082 ,  B01J2219/083 ,  B01J2219/0841 ,  B01J2219/0869 ,  B01J2219/0871 ,  B01J2219/0877 ,  B22F9/20 ,  B22F2999/00 ,  B82Y30/00 ,  B82Y40/00 ,  B22F2202/06 ,  B22F2202/13

摘要： This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, zeta potential and properties present in a liquid.

摘要翻译： 本发明一般涉及用于连续制造纳米颗粒，微粒和纳米颗粒/液体溶液的新颖方法和新型装置。 纳米颗粒（和/或微米尺寸的颗粒）包含各种可能的组合物，尺寸和形状。 引起颗粒（例如，纳米颗粒）存在（例如，通过例如优选利用至少一种的方式在液体（例如水）中存在（例如，产生和/或将液体倾向于其存在（例如，调节）） 可调节的等离子体（例如，由至少一个AC和/或DC电源产生），其等离子体与液体的至少一部分表面连通。 至少一个后续和/或基本上同时可调节的电化学处理技术也是优选的。 多重可调等离子体和/或可调电化学处理技术是优选的。 连续过程使至少一种液体流入，通过和流出至少一个槽构件，这种液体在所述槽构件中被处理，调节和/或实现。 结果包括在液体中形成的成分，包括具有新颖尺寸，形状，组成，ζ电位和存在于液体中的性质的微米级颗粒和/或纳米颗粒（例如金属基纳米颗粒）。

公开(公告)号：US20210052638A1

公开(公告)日：2021-02-25

申请号：US16501474

申请日：2019-10-09

申请人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

发明人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

IPC分类号： A61K33/30 ,  B01J19/08 ,  A61K9/51 ,  A61K33/38

摘要： This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, zeta potential and properties present in a liquid.

公开(公告)号：US10441608B2

公开(公告)日：2019-10-15

申请号：US15199009

申请日：2016-06-30

申请人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

发明人： David Kyle Pierce ,  Mark G. Mortenson ,  David A. Bryce

IPC分类号： A61K33/30 ,  B01J19/08 ,  A61K9/51 ,  A61K33/38

摘要： This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, zeta potential and properties present in a liquid.

公开(公告)号：US09743672B2

公开(公告)日：2017-08-29

申请号：US14081725

申请日：2013-11-15

申请人： David K. Pierce ,  Mark G. Mortenson ,  David A. Bryce

发明人： David K. Pierce ,  Mark G. Mortenson ,  David A. Bryce

IPC分类号： A01N59/16 ,  B22F3/00 ,  B01J19/08 ,  C22B3/02 ,  C22B3/22 ,  A01N59/00 ,  H05H1/48 ,  C22B4/00 ,  C22B4/08

CPC分类号： A01N59/16 ,  A01N59/00 ,  B01J19/088 ,  B01J2219/0811 ,  B01J2219/0894 ,  B22F3/003 ,  B22F2999/00 ,  C22B3/02 ,  C22B3/22 ,  C22B4/005 ,  C22B4/08 ,  H05H1/48 ,  H05H2001/483 ,  Y02P10/234 ,  B22F9/14 ,  B22F2202/13 ,  B22F1/0018 ,  C25C5/02

摘要： This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition and properties present in a liquid.