发明申请
- 专利标题： IDO Inhibitors
- 专利标题（中）： IDO抑制剂
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申请号： US14264974申请日： 2014-04-29
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公开(公告)号： US20140323740A1公开(公告)日： 2014-10-30
- 发明人: Mario R. Mautino , Sanjeev Kumar , Firoz Jaipuri , Jesse Waldo , Tanay Kesharwani , Nicholas N. Vahanian , Charles J. Link , Judith Lalonde , George Prendergast , Alexander Muller , William Malachowski
- 申请人： NewLink Genetics Corporation , Lankeanau Institute for Medical Research
- 申请人地址： US IA Ames US PA Wynnewood
- 专利权人： NewLink Genetics Corporation,Lankeanau Institute for Medical Research
- 当前专利权人： NewLink Genetics Corporation,Lankeanau Institute for Medical Research
- 当前专利权人地址： US IA Ames US PA Wynnewood
- 主分类号： C07D233/64
- IPC分类号： C07D233/64
摘要：
Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R1, R4, and R5 are defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine -2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.
公开/授权文献
- US09174942B2 IDO inhibitors 公开/授权日：2015-11-03
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