公开(公告)号：US20140323740A1

公开(公告)日：2014-10-30

申请号：US14264974

申请日：2014-04-29

申请人： NewLink Genetics Corporation ,  Lankeanau Institute for Medical Research

发明人： Mario R. Mautino ,  Sanjeev Kumar ,  Firoz Jaipuri ,  Jesse Waldo ,  Tanay Kesharwani ,  Nicholas N. Vahanian ,  Charles J. Link ,  Judith Lalonde ,  George Prendergast ,  Alexander Muller ,  William Malachowski

IPC分类号： C07D233/64

CPC分类号： C07D233/64 ,  A61K31/4174 ,  C07D233/56 ,  C07D233/58 ,  C07D233/60 ,  C07D233/61 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/06 ,  C07D498/04 ,  C07H19/067 ,  Y02A50/409 ,  Y02A50/465

摘要： Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R1, R4, and R5 are defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine -2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.

摘要翻译： 目前提供的是根据式（I）或（II）的化合物，以及包含化合物的药物组合物，其中R 1，R 4和R 5在本文中定义。 这些化合物和组合物可用于调节吲哚胺2,3-双加氧酶的活性; 治疗吲哚胺2,3-双加氧酶（IDO）介导的免疫抑制; 治疗受抑制吲哚胺-2,3-双加氧酶的酶活性的医学病症; 提高抗癌治疗的有效性，包括施用抗癌剂; 治疗与癌症有关的肿瘤特异性免疫抑制; 并治疗与感染性疾病相关的免疫抑制。

公开(公告)号：US09174942B2

公开(公告)日：2015-11-03

申请号：US14264974

申请日：2014-04-29

申请人： NewLink Genetics Corporation ,  Lankeanau Institute for Medical Research

发明人： Mario R. Mautino ,  Sanjeev Kumar ,  Firoz Jaipuri ,  Jesse Waldo ,  Tanay Kesharwani ,  Nicholas N. Vahanian ,  Charles J. Link ,  Judith Lalonde ,  George Prendergast ,  Alexander Muller ,  William Malachowski

IPC分类号： A61K31/4174 ,  C07D233/64 ,  C07D233/56 ,  C07D233/58 ,  C07D233/60 ,  C07D233/61 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/06 ,  C07D498/04 ,  C07H19/067

CPC分类号： C07D233/64 ,  A61K31/4174 ,  C07D233/56 ,  C07D233/58 ,  C07D233/60 ,  C07D233/61 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/06 ,  C07D498/04 ,  C07H19/067 ,  Y02A50/409 ,  Y02A50/465

摘要： Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R1, R4, and R5 are defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease.

摘要翻译： 目前提供的是根据式（I）或（II）的化合物，以及包含化合物的药物组合物，其中R 1，R 4和R 5在本文中定义。 这些化合物和组合物可用于调节吲哚胺2,3-双加氧酶的活性; 治疗吲哚胺2,3-双加氧酶（IDO）介导的免疫抑制; 治疗受抑制吲哚胺-2,3-双加氧酶酶活性的医学病症; 提高抗癌治疗的有效性，包括给予抗癌剂; 治疗与癌症有关的肿瘤特异性免疫抑制; 并治疗与感染性疾病相关的免疫抑制。