A method and a system for communication between devices in proximity, a network side device and a User Equipment (UE) are disclosed. The method includes that: a network side device determines whether UEs meet a direct Device to Device (D2D) communication condition; when the network side device determines that the UEs meet the direct D2D communication condition, the network side device informs the UEs of the result of the determination, and configures resources for direct D2D communication for the UEs according to requirements of the UEs; and when the network side device determines that the UEs do not meet the direct D2D communication condition, the network side device configures resources for architecture communication for the UEs according to the requirements of the UEs. The disclosure can implement D2D communication between devices in proximity, reduce network load and relieve the dependence of the D2D communication on a network.