发明申请
US20140329331A1 NOVEL CYANINE DERIVATIVES HAVING MESO-REACTIVE FUNCTIONAL GROUP AT POLYMETHINE CHAIN AND PREPARATION METHOD THEREOF
有权
在聚四氟乙烯链上具有MESO反应性官能团的新型氰胺衍生物及其制备方法
- 专利标题： NOVEL CYANINE DERIVATIVES HAVING MESO-REACTIVE FUNCTIONAL GROUP AT POLYMETHINE CHAIN AND PREPARATION METHOD THEREOF
- 专利标题（中）： 在聚四氟乙烯链上具有MESO反应性官能团的新型氰胺衍生物及其制备方法
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申请号： US13813764申请日： 2013-01-07
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公开(公告)号： US20140329331A1公开(公告)日： 2014-11-06
- 发明人: Juyoung Yoon , Guo Zhiqian
- 申请人： EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION
- 申请人地址： KR Seoul
- 专利权人： EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION
- 当前专利权人： EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION
- 当前专利权人地址： KR Seoul
- 优先权： KR10-2012-0006796 20120120
- 国际申请： PCT/KR2013/000089 WO 20130107
- 主分类号： G01N31/22
- IPC分类号： G01N31/22 ; C07D403/08
摘要：
The present invention relates to a novel cyanne derivative having a meso-reaction functional group in a polymethine chain, and a preparation method thereof, and the cyanine derivative having the reaction functional group substituted at the meso site may be suitable for mass production thanks to a very simple synthesis method, have a very fast reaction rate because while a related art reagent for detection of nerve agents undergoes two steps of reactions, the cyanine derivative of the present invention undergoes only one step of reaction, have very excellent sensitivity, and be useful as an acid pH-activated ratiometric NIR probe because it is able to be activated in an acidic pH and is usable in an aqueous environment.
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