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公开(公告)号：US20170240557A1
公开(公告)日：2017-08-24
申请号：US15440748
申请日：2017-02-23
Inventor： Juyoung Yoon , Xin Zhou , Ying Hu , Liyan Chen
IPC: C07D491/107 , C07D221/14 , G01N21/78 , C07D271/12 , G01N21/64 , C07D311/88 , C07D209/14
CPC classification number: C07D491/107 , C07D209/14 , C07D221/14 , C07D271/12 , C07D311/88 , G01N2021/7783 , G01N2021/7786
Abstract: The present invention relates to a compound for detecting phosgene and DCP (diethyl chlorophosphate) and a composition for detecting phosgene and DCP (diethyl chlorophosphate) comprising the said compound. More precisely, the compound for detecting phosgene and DCP of the present invention can selectively detect phosgene and DCP either in the liquid phase of gas phase by detecting the changes of fluorescence and color development very quickly within a few seconds with nM sensitivity. Therefore, the compound can also be effectively used as an ingredient for the composition and kit for the detection of one or more materials selected from the group consisting of phosgene and DCP.
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Patent Agency Ranking
2.发明申请NOVEL CYANINE DERIVATIVES HAVING MESO-REACTIVE FUNCTIONAL GROUP AT POLYMETHINE CHAIN AND PREPARATION METHOD THEREOF 有权在聚四氟乙烯链上具有MESO反应性官能团的新型氰胺衍生物及其制备方法公开(公告)号：US20140329331A1
公开(公告)日：2014-11-06
申请号：US13813764
申请日：2013-01-07
Inventor： Juyoung Yoon , Guo Zhiqian
IPC: G01N31/22 , C07D403/08
CPC classification number: G01N31/221 , C07D209/14 , C07D403/08 , C09B23/0041 , C09B23/0066 , G01N33/84 , Y10T436/163333
Abstract: The present invention relates to a novel cyanne derivative having a meso-reaction functional group in a polymethine chain, and a preparation method thereof, and the cyanine derivative having the reaction functional group substituted at the meso site may be suitable for mass production thanks to a very simple synthesis method, have a very fast reaction rate because while a related art reagent for detection of nerve agents undergoes two steps of reactions, the cyanine derivative of the present invention undergoes only one step of reaction, have very excellent sensitivity, and be useful as an acid pH-activated ratiometric NIR probe because it is able to be activated in an acidic pH and is usable in an aqueous environment.
Abstract translation: 本发明涉及一种在聚甲炔链中具有内消旋反应官能团的新型氰化物衍生物及其制备方法，并且具有在中间位置被取代的反应官能团的花青衍生物可适用于批量生产 非常简单的合成方法，具有非常快的反应速率，因为当用于检测神经药物的现有技术试剂经历两步反应时，本发明的花青衍生物仅经历一个反应步骤，具有非常优异的灵敏度，并且是有用的 作为酸性pH活化的比率NIR探针，因为它能够在酸性pH下活化并且可用于水性环境中。
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3.发明授权公开(公告)号：US09951226B2
公开(公告)日：2018-04-24
申请号：US14663990
申请日：2015-03-20
Inventor： Juyoung Yoon , Jun Yin , Gyoungmi Kim , Dabin Kim
IPC: C09B23/01 , C07D209/14 , G01N33/68 , C07D401/14
CPC classification number: C09B23/0066 , C07D209/14 , C07D401/14 , G01N33/6815 , G01N2800/26
Abstract: The present invention relates to a compound based on cyanine scaffold for diagnosing sepsis by selectively detecting glutathione. The compound based on cyanine scaffold according to the present invention has the advantages of maintaining its structure in intracellular environment and of reacting selectively to glutathione only among many amino acids containing thiol group (R—SH) such as cysteine, homocysteine, and glutathione, to produce changes in absorption or fluorescence spectrum, making the compound useful for the detection of in vivo glutathione in biosamples and also for the diagnosis of sepsis characteristically displaying the changes of glutathione concentration.
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公开(公告)号：US12181409B2
公开(公告)日：2024-12-31
申请号：US17741512
申请日：2022-05-11
Inventor： Kwan Mook Kim , Juyoung Yoon , Sun Shin Cha , Ah-Young Song
Abstract: The present disclosure relates to a composition for cell imaging including a probe compound, and a method of cell-material imaging using the same. The composition for cell imaging and the method of cell-material imaging are provided to image the material in the cell by measuring fluorescence generated by reacting the probe and a material in a cell.
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公开(公告)号：US11780857B2
公开(公告)日：2023-10-10
申请号：US16852039
申请日：2020-04-17
Inventor： Kwan Mook Kim , Juyoung Yoon , Eknath Shirbhate Mukesh , Ah-Young Song
CPC classification number: C07F5/025 , G01N21/19 , G01N21/6428 , G01N21/77 , G01N2021/6439 , G01N2021/7786 , Y10T436/173845
Abstract: The present disclosure relates to a novel probe compound, i.e., 1-(ortho-benzophenylaminoalkyl)-phenylboronic acid, or its derivative for a fluorescence and/or circular dichroism (CD) sensor for amine compounds containing aminoalcohols. Also, the present disclosure relates to a simultaneous fluorescence and CD analysis method of of amine compounds containing aminoalcohols using the novel probe compound to obtain concentration and optical purity of the amine compounds.
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6.发明授权Cyanine derivatives having meso-reactive functional group at polymethine chain and preparation method thereof 有权在聚甲炔链上具有中等反应性官能团的花青衍生物及其制备方法公开(公告)号：US09151735B2
公开(公告)日：2015-10-06
申请号：US13813764
申请日：2013-01-07
Inventor： Juyoung Yoon , Guo Zhiqian
IPC: G01N31/22 , G01N31/00 , C07D403/08 , C07D403/02 , C07D209/14 , G01N33/84 , C09B23/01
CPC classification number: G01N31/221 , C07D209/14 , C07D403/08 , C09B23/0041 , C09B23/0066 , G01N33/84 , Y10T436/163333
Abstract: The present invention relates to a novel cyanne derivative having a meso-reaction functional group in a polymethine chain, and a preparation method thereof, and the cyanine derivative having the reaction functional group substituted at the meso site may be suitable for mass production thanks to a very simple synthesis method, have a very fast reaction rate because while a related art reagent for detection of nerve agents undergoes two steps of reactions, the cyanine derivative of the present invention undergoes only one step of reaction, have very excellent sensitivity, and be useful as an acid pH-activated ratiometric NIR probe because it is able to be activated in an acidic pH and is usable in an aqueous environment.
Abstract translation: 本发明涉及一种在聚甲炔链中具有内消旋反应官能团的新型氰化物衍生物及其制备方法，并且具有在中间位置被取代的反应官能团的花青衍生物可适用于批量生产 非常简单的合成方法，具有非常快的反应速率，因为当用于检测神经药物的现有技术试剂经历两步反应时，本发明的花青衍生物仅经历一个反应步骤，具有非常优异的灵敏度，并且是有用的 作为酸性pH活化的比率NIR探针，因为它能够在酸性pH下活化并且可用于水性环境中。
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