发明申请
- 专利标题： Amine Derivatives as Potassium Channel Blockers
- 专利标题（中）： 胺衍生物作为钾通道阻断剂
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申请号： US14118170申请日： 2012-05-16
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公开(公告)号： US20140336198A1公开(公告)日： 2014-11-13
- 发明人: Andrew Harvey , Agnes Bombrun , Rachel Cooke , Isabelle Jeanclaude-Etter , Nathan Kuchel , Jerome Molette , Jorgen Mould , Dharam Paul , Rajinder Singh , Cristina Donini , Veronique Colovray , Thomas Avery , Julia Crossman , Justin Ripper
- 申请人： Andrew Harvey , Agnes Bombrun , Rachel Cooke , Isabelle Jeanclaude-Etter , Nathan Kuchel , Jerome Molette , Jorgen Mould , Dharam Paul , Rajinder Singh , Cristina Donini , Veronique Colovray , Thomas Avery , Julia Crossman , Justin Ripper
- 申请人地址： DE Darmstadt AU SA Thebarton
- 专利权人： MERCK PATENT GMBH,BIONOMICS LIMITED
- 当前专利权人： MERCK PATENT GMBH,BIONOMICS LIMITED
- 当前专利权人地址： DE Darmstadt AU SA Thebarton
- 国际申请： PCT/AU2012/000538 WO 20120516
- 主分类号： C07D451/04
- IPC分类号： C07D451/04 ; C07D405/12 ; C07D411/12 ; C07D213/64 ; C07D413/12 ; C07D237/08 ; C07D241/18 ; C07D213/40 ; C07D401/12
摘要：
The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
公开/授权文献
- US09493451B2 Amine derivatives as potassium channel blockers 公开/授权日：2016-11-15
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