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公开(公告)号：US09133188B2
公开(公告)日：2015-09-15
申请号：US14116196
申请日：2012-05-11
IPC分类号： C07D471/04 , A61K31/4375 , C07D213/76
CPC分类号： C07D471/04 , A61K31/4375 , C07D213/76
摘要： The present invention provides methods of synthesizing compounds of formula (1) and intermediates thereto. The present invention also provides intermediates useful in the synthesis of compounds of formula (1).
摘要翻译： 本发明提供合成式（1）化合物及其中间体的方法。 本发明还提供了可用于合成式（1）化合物的中间体。
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公开(公告)号：US20140336198A1
公开(公告)日：2014-11-13
申请号：US14118170
申请日：2012-05-16
申请人： Andrew Harvey , Agnes Bombrun , Rachel Cooke , Isabelle Jeanclaude-Etter , Nathan Kuchel , Jerome Molette , Jorgen Mould , Dharam Paul , Rajinder Singh , Cristina Donini , Veronique Colovray , Thomas Avery , Julia Crossman , Justin Ripper
发明人： Andrew Harvey , Agnes Bombrun , Rachel Cooke , Isabelle Jeanclaude-Etter , Nathan Kuchel , Jerome Molette , Jorgen Mould , Dharam Paul , Rajinder Singh , Cristina Donini , Veronique Colovray , Thomas Avery , Julia Crossman , Justin Ripper
IPC分类号： C07D451/04 , C07D405/12 , C07D411/12 , C07D213/64 , C07D413/12 , C07D237/08 , C07D241/18 , C07D213/40 , C07D401/12
CPC分类号： C07D213/40 , C07C217/90 , C07D209/52 , C07D211/16 , C07D211/26 , C07D211/38 , C07D213/16 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/89 , C07D231/12 , C07D233/56 , C07D237/08 , C07D239/24 , C07D239/34 , C07D241/12 , C07D241/18 , C07D309/14 , C07D401/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D451/04
摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
摘要翻译： 本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。
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公开(公告)号：US20140088104A1
公开(公告)日：2014-03-27
申请号：US14002243
申请日：2012-03-02
申请人： Bernard Luke Flynn , Dharam Paul , Andrew John Harvey , Damian Wojciech , Sue O'Connor , Jonathan Bayldon Baell , Brad Sleebs , Ian Phillip Street
发明人： Bernard Luke Flynn , Dharam Paul , Andrew John Harvey , Damian Wojciech , Sue O'Connor , Jonathan Bayldon Baell , Brad Sleebs , Ian Phillip Street
IPC分类号： C07D215/54
CPC分类号： C07D215/54 , C07D215/38 , C07D401/04 , C07D413/04 , C07D491/107
摘要： The present invention provides compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful in treating central nervous system disorders, such as anxiety disorders or depression.
摘要翻译： 本发明提供式（I）化合物，其药学上可接受的盐及其药物组合物。 本发明的化合物可用于治疗中枢神经系统疾病，例如焦虑障碍或抑郁症。
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公开(公告)号：US20140128600A1
公开(公告)日：2014-05-08
申请号：US14116196
申请日：2012-05-11
IPC分类号： C07D471/04 , C07D213/76
CPC分类号： C07D471/04 , A61K31/4375 , C07D213/76
摘要： The present invention provides methods of synthesizing compounds of formula (1) and intermediates thereto. The present invention also provides intermediates useful in the synthesis of compounds of formula (1).
摘要翻译： 本发明提供合成式（1）化合物及其中间体的方法。 本发明还提供了可用于合成式（1）化合物的中间体。
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5.发明申请Positive Allosteric Modulators of the Alpha 7 Nicotinic Acetylcholine Receptor and uses Thereof 有权α7烟碱乙酰胆碱受体的正变构调节剂及其用途公开(公告)号：US20140031395A1
公开(公告)日：2014-01-30
申请号：US13983476
申请日：2012-02-02
申请人： Andrew Harvey , Audrey Fluck , Bruno Giethlen , Dharam Paul , Laurent Schaeffer
发明人： Andrew Harvey , Audrey Fluck , Bruno Giethlen , Dharam Paul , Laurent Schaeffer
IPC分类号： C07D277/46 , C07D213/75 , C07C311/46 , C07D231/40 , C07C233/60
CPC分类号： A61K31/4412 , A61K31/167 , A61K31/357 , A61K31/415 , A61K31/426 , A61K31/4409 , C07C233/59 , C07C233/60 , C07C311/16 , C07C311/46 , C07C2601/02 , C07C2602/50 , C07D209/46 , C07D213/75 , C07D231/40 , C07D275/06 , C07D277/46 , C07D317/46
摘要： The present invention relates to compounds useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of α7nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also inflammatory diseases.
摘要翻译： 本发明涉及可用于阳性调节α7烟碱乙酰胆碱受体（α7nAChR）的化合物。 本发明还涉及这些化合物在治疗或预防广泛范围的疾病中的用途，其中α7nAChR的阳性调节是有利的，包括神经变性和神经精神疾病以及炎性疾病。
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公开(公告)号：US08309545B2
公开(公告)日：2012-11-13
申请号：US12444211
申请日：2007-10-04
申请人： Bernard Luke Flynn , Jonathan B. Baell , Andrew J. Harvey , Jason Hugh Chaplin , Dharam Paul , Jorgen Alvar Mould
发明人： Bernard Luke Flynn , Jonathan B. Baell , Andrew J. Harvey , Jason Hugh Chaplin , Dharam Paul , Jorgen Alvar Mould
IPC分类号： A61K31/5377 , A61K31/343 , C07D413/12 , C07D307/78
CPC分类号： C07D307/79 , C07D405/12 , C07D413/12
摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
摘要翻译： 本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。
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公开(公告)号：US20100297077A1
公开(公告)日：2010-11-25
申请号：US12681763
申请日：2008-10-03
申请人： Bernard Luke Flynn , Jonathan Bayldon Baell , Jason Hugh Chaplin , Girmit Singh Gill , Damian Wojciech Grobelny , Andrew John Harvey , Jorgen Alvar Mould , Dharam Paul
发明人： Bernard Luke Flynn , Jonathan Bayldon Baell , Jason Hugh Chaplin , Girmit Singh Gill , Damian Wojciech Grobelny , Andrew John Harvey , Jorgen Alvar Mould , Dharam Paul
IPC分类号： A61K38/21 , C07C215/64 , A61K31/138 , C07D213/54 , A61K31/4402 , C07D265/30 , A61K31/5375 , C07D211/34 , A61K31/4453 , C07D207/08 , A61K31/40 , C07D211/74 , C07D241/18 , A61K31/4965 , C07D279/12 , A61K31/54 , C07D233/60 , A61K31/4174 , C07D249/08 , A61K31/4196 , C07D205/04 , A61K31/397 , A61K31/198 , A61K39/395 , A61P29/00 , A61P3/10 , A61P25/28
CPC分类号： C07C217/22 , C07C49/84 , C07C2601/08 , C07D205/04 , C07D205/08 , C07D207/10 , C07D211/38 , C07D211/46 , C07D211/74 , C07D213/30 , C07D233/60 , C07D241/18 , C07D249/08 , C07D265/30 , C07D295/088
摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
摘要翻译： 本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。
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公开(公告)号：US20100087430A1
公开(公告)日：2010-04-08
申请号：US12444211
申请日：2007-10-04
申请人： Bernard Luke Flynn , Jonathan B. Baell , Andrew J. Harvey , Jason Hugh Chaplin , Dharam Paul , Jorgen Alvar Mould
发明人： Bernard Luke Flynn , Jonathan B. Baell , Andrew J. Harvey , Jason Hugh Chaplin , Dharam Paul , Jorgen Alvar Mould
IPC分类号： A61K31/5377 , C07D307/78 , C07D413/12 , A61K31/343 , A61P3/10 , A61P37/00
CPC分类号： C07D307/79 , C07D405/12 , C07D413/12
摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
摘要翻译： 本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。
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公开(公告)号：US20090298931A1
公开(公告)日：2009-12-03
申请号：US12442790
申请日：2007-10-04
申请人： Bernard Luke Flynn , Jonathan B. Baell , Andrew J. Harvey , Jason Hugh Chaplin , Dharam Paul , Jorgen Alvar Mould
发明人： Bernard Luke Flynn , Jonathan B. Baell , Andrew J. Harvey , Jason Hugh Chaplin , Dharam Paul , Jorgen Alvar Mould
IPC分类号： A61K31/35 , C07D493/04
CPC分类号： C07D493/04
摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
摘要翻译： 本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。
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10.发明授权Positive allosteric modulators of the α7 nicotinic acetylcholine receptor and uses thereof 有权α7烟碱乙酰胆碱受体的正变构调节剂及其用途公开(公告)号：US09062013B2
公开(公告)日：2015-06-23
申请号：US13983476
申请日：2012-02-02
申请人： Andrew Harvey , Audrey Fluck , Bruno Giethlen , Dharam Paul , Laurent Schaeffer
发明人： Andrew Harvey , Audrey Fluck , Bruno Giethlen , Dharam Paul , Laurent Schaeffer
IPC分类号： C07D213/75 , C07D231/40 , C07D277/46 , C07C311/46 , C07C233/60 , A61K31/44 , A61K31/167 , A61K31/36 , A61K31/63 , C07C233/59 , C07C311/16 , C07D317/46 , C07D275/06 , C07D209/46
CPC分类号： A61K31/4412 , A61K31/167 , A61K31/357 , A61K31/415 , A61K31/426 , A61K31/4409 , C07C233/59 , C07C233/60 , C07C311/16 , C07C311/46 , C07C2601/02 , C07C2602/50 , C07D209/46 , C07D213/75 , C07D231/40 , C07D275/06 , C07D277/46 , C07D317/46
摘要： The present invention relates to compounds useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of α7nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also inflammatory diseases.
摘要翻译： 本发明涉及可用于阳性调节α7烟碱乙酰胆碱受体（α7nAChR）的化合物。 本发明还涉及这些化合物在治疗或预防α7nAChR的阳性调节有利的广泛范围的疾病中的应用，包括神经变性和神经精神疾病以及炎性疾病。
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