发明申请
- 专利标题: HYDROXY GROUP PROTECTING AGENT AND HYDROXY GROUP PROTECTION METHOD
- 专利标题(中): 羟基保护剂和羟基保护方法
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申请号: US14359183申请日: 2012-11-16
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公开(公告)号: US20140343281A1公开(公告)日: 2014-11-20
- 发明人: Munetaka Kunishima , Hikaru Fujita , Kohei Yamada
- 申请人: Munetaka Kunishima , Hikaru Fujita , Kohei Yamada
- 申请人地址: JP Kanazawa-shi, Ishikawa
- 专利权人: NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY
- 当前专利权人: NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY
- 当前专利权人地址: JP Kanazawa-shi, Ishikawa
- 优先权: JP2011-253002 20111118
- 国际申请: PCT/JP2012/079834 WO 20121116
- 主分类号: C07D251/30
- IPC分类号: C07D251/30 ; C07C67/62
摘要:
To provide: a hydroxy group protecting agent which is stable and easy to use, does not have carcinogenicity, a tearing property or the like, and is inexpensive; and a hydroxy group protection method which enables the protection of a hydroxy group under acidic conditions.[Solution] A hydroxy group protecting agent in which at least one protecting group is bound to a nitrogen-containing electron-withdrawing heterocyclic ring through any one of an oxygen atom, a sulfur atom and a nitrogen atom. The heterocyclic ring is a triazine ring or the like, and the protecting group is a benzyl group or the like. Specifically, the hydroxy group protecting agent is 2,4,6-tribenzyloxy-1,3,5-triazine, 2,4,6-tris(4-methoxybenzyloxy)-1,3,5-triazine or the like. In addition, 2,4,6-tris(t-butoxy)-1,3,5-triazine or the like can also be used. For protecting a hydroxy group, a compound of interest which has a hydroxy group is reacted with the hydroxy group protecting agent under acidic conditions.
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