Methods for preparing edge-sealed multi-layer film articles include applying a sealant composition to a multi-layer film article that includes at least one polymeric film layer, and permitting the sealant composition to dry to form an edge-sealed article. The sealant composition includes at least one solvent capable of softening, penetrating or dissolving the polymeric film layer of the multi-layer film article, and at least one polymer dissolved in the solvent. The polymer dissolved in the solvent may be a fluoropolymer, a non-tacky at ambient temperatures(meth)acrylate-based block copolymer, or a combination thereof. Edge-sealed articles prepared by this method can include other polymeric film layers or coated layers such as metallic layers and can be part of larger assemblies.