A video encoder may generate a bitstream that includes a syntax element that indicates whether inter-layer prediction is enabled for decoding a tile of a picture of the video data. Similarly, a video decoder may obtain, from a bitstream, a syntax element that indicates whether inter-layer prediction is enabled. The video decoder may determine, based on the syntax element, whether inter-layer prediction is enabled for decoding a tile of a picture of the video data, and decode the tile based on the determination.