发明申请
- 专利标题： DIAGNOSIS AND TREATMENT OF TRAUMATIC BRAIN INJURY
- 专利标题（中）： 诊断和治疗TRAUMATIC脑损伤
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申请号： US14006557申请日： 2012-05-03
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公开(公告)号： US20150030609A1公开(公告)日： 2015-01-29
- 发明人: Subhra Mohapatra , Shyam S. Mohapatra , Keith Ronald Pennypacker , Mahasweta Das , Christopher Charles Leonardo
- 申请人： Subhra Mohapatra , Shyam S. Mohapatra , Keith Ronald Pennypacker , Mahasweta Das , Christopher Charles Leonardo
- 申请人地址： US FL Tampa
- 专利权人： UNIVERSITY OF SOUTH FLORIDA
- 当前专利权人： UNIVERSITY OF SOUTH FLORIDA
- 当前专利权人地址： US FL Tampa
- 国际申请： PCT/US12/36335 WO 20120503
- 主分类号： G01N33/68
- IPC分类号： G01N33/68 ; C07K16/24
摘要：
The subject invention identifies CC chemokine ligand 20 (CCL20) as a novel biomarker for diagnosis of traumatic brain injury and/or neurodegeneration in the brain. The subject invention also provides treatment methods for traumatic brain injury and/or neurodegeneration in the brain by modulating systemic and/or brain-specific CCL20-CCR6 signaling. Also provided are uses of CCL20-CCR6 signaling a target for screening for therapeutic agents that are useful for treatment of traumatic brain injury.
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