发明申请
US20150079625A1 NAPHTHALENE-BASED TWO-PHOTON FLUORESCENT PROBES, PREPARATION METHOD AND USE THEREOF
有权
基于萘基的双光子荧光探针，其制备方法和用途
- 专利标题： NAPHTHALENE-BASED TWO-PHOTON FLUORESCENT PROBES, PREPARATION METHOD AND USE THEREOF
- 专利标题（中）： 基于萘基的双光子荧光探针，其制备方法和用途
-
申请号： US14383000申请日： 2012-03-05
-
公开(公告)号： US20150079625A1公开(公告)日： 2015-03-19
- 发明人: Xiaojun Peng , Hua Zhang , Jiangli Fan , Jingyun Wang
- 申请人： Xiaojun Peng , Hua Zhang , Jiangli Fan , Jingyun Wang
- 申请人地址： CN Dalian, Liaong CN Dalian, Liaoning
- 专利权人： DALIAN CHROMAS BIOSCIENCE CO., LTD,DALIAN UNIVERSITY OF TECHNOLOGY
- 当前专利权人： DALIAN CHROMAS BIOSCIENCE CO., LTD,DALIAN UNIVERSITY OF TECHNOLOGY
- 当前专利权人地址： CN Dalian, Liaong CN Dalian, Liaoning
- 国际申请： PCT/CN2012/071940 WO 20120305
- 主分类号： G01N21/64
- IPC分类号： G01N21/64 ; C07D471/06 ; C07D403/12 ; C07D401/12
摘要：
The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X1, X2, X3 and X4; The mentioned two-photon fluorescent probes have a low fluorescence background in the non-tumor cells and tissues, and have a strong and specific fluorescent signal in the tumor cells and tissues. These probes have a certain level of water-solubility, while having good membrane permeability. In addition, they have a bigger effective two-photon absorption cross section. The compounds of the present invention also have a lower biotoxicity, phototoxicity and photobleaching. There is sufficient difference between the spectral range thereof and that of a biological sample.
公开/授权文献
信息查询
