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    FLUORESCENT PROBE COMPOUNDS, PREPARATION METHOD AND USE THEREOF
    1.
    发明申请
    FLUORESCENT PROBE COMPOUNDS, PREPARATION METHOD AND USE THEREOF 有权
    荧光探针化合物，制备方法及其用途

    公开(公告)号：US20130137879A1

    公开(公告)日：2013-05-30

    申请号：US13513862

    申请日：2010-12-03

    Applicant: Xiaojun Peng ,  Jiangli Fan ,  Jianjun Du ,  Jingyun Wang ,  Jianzhou Zhang ,  Shiguo Sun

    Inventor： Xiaojun Peng ,  Jiangli Fan ,  Jianjun Du ,  Jingyun Wang ,  Jianzhou Zhang ,  Shiguo Sun

    IPC: C09B11/24

    CPC classification number: C07D491/107 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/1088 ,  G01N21/643 ,  H05B33/10

    Abstract: A fluorescence probe compound, its preparation method and use are provided. The said compound is represented by the general formula I, wherein, each of R1, R2, R3 and R4 is individually selected from the group consisting of H, C1-18 alkyl, phenyl substituted by C1-18 alkyl, naphthyl substituted by C1-18 alkyl, halogen, OR9, N(R9)2, cyano group, (CH2CH2O)nH, (CH2)mCOOH and (CH2)mSO3M; each of R5, R6, R7 and R8 is individually selected from the group consisting of H, C1-18 alkyl, phenyl substituted by C1-18 alkyl, naphthyl substituted by C1-18 alkyl, halogen, hydroxyl, mercapto group, cyano group, nitro group, heterocyclic group, halogenated alkyl, alkyl amino group, acylamino group, OR9, N(R9)2, (CH2CH2O)nH, (CH2)mCOOH and (CH2)mSO3M; R9 represents H, C1-18 alkyl, phenyl substituted by C1-18 alkyl, naphthyl substituted by C1-18 alkyl, halogen, cyano group, (CH2CH2O)nH, (CH2)mCOOH or (CH2)mSO3M; n and m each individually represent integer of 0 to 8; M represents H, K, Na, Li, NH4, NH3R10, NH2(R10)2, NH(R10)3 or N(R10)4; and R10 represents H, C1-6 alkyl or CH2CH2OH. The compound is useful for detecting mercury ion.

    Abstract translation: 提供荧光探针化合物及其制备方法和用途。 所述化合物由通式I表示，其中R1，R2，R3和R4各自独立地选自H，C1-18烷基，被C1-18烷基取代的苯基，被C1- 18烷基，卤素，OR 9，N（R 9）2，氰基，（CH 2 CH 2 O）n H，（CH 2）m COOH和（CH 2）m SO 3 M; R5，R6，R7和R8各自独立地选自H，C1-18烷基，被C1-18烷基取代的苯基，被C1-18烷基取代的萘基，卤素，羟基，巯基，氰基， 硝基，杂环基，卤代烷基，烷基氨基，酰氨基，OR9，N（R9）2，（CH2CH2O）nH，（CH2）mCOOH和（CH2）mSO3M; R9代表H，C1-18烷基，被C1-18烷基取代的苯基，被C1-18烷基取代的萘基，卤素，氰基，（CH2CH2O）nH，（CH2）mCOOH或（CH2）mSO3M; n和m各自独立地表示0〜8的整数。 M代表H，K，Na，Li，NH4，NH3R10，NH2（R10）2，NH（R10）3或N（R10） R 10表示H，C 1-6烷基或CH 2 CH 2 OH。 该化合物可用于检测汞离子。

    Pentamethine Cyanine Fluorescent Dye with N-substituting at Beta-Position of Conjugated Chain
    2.
    发明申请
    Pentamethine Cyanine Fluorescent Dye with N-substituting at Beta-Position of Conjugated Chain 有权
    Pentamethine Cyanine荧光染料在共轭链的β位置取代

    公开(公告)号：US20120296098A1

    公开(公告)日：2012-11-22

    申请号：US13521046

    申请日：2010-12-06

    Applicant: Xiaojun Peng ,  Zhigang Yang ,  Fengling Song ,  Yanxia He ,  Shiguo Sun ,  Jiangli Fan

    Inventor： Xiaojun Peng ,  Zhigang Yang ,  Fengling Song ,  Yanxia He ,  Shiguo Sun ,  Jiangli Fan

    IPC: C07D403/06

    CPC classification number: C07D403/06 ,  C09B23/0016 ,  C09B23/0041 ,  C09B23/083 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  G01N2021/6439

    Abstract: A pentamethine cyanine fluorescent dye with N-substituting at β-position of conjugated chain is disclosed. The dye reacts with biosubstrate including protein, liposome and DNA, and shows excellent selectivity. It has good living cell membrane permeability and shows good selectivity in living cell staining In addition, the dye has good stability and low background fluorescence, and can be used together with other fluorescent dyes having consistent wavelengths for single-channel excitation and multi-channel detection. The dye can be used in the fields of protein labeling and detecting, fluorescence immunoassay and living cell selective imaging and the like.

    Abstract translation: 公开了在共轭链的位置上具有N取代的五甲代花青荧光染料。 染料与包括蛋白质，脂质体和DNA在内的生物底物反应，显示出优异的选择性。 它具有良好的活细胞膜渗透性，并且在活细胞染色中表现出良好的选择性。此外，染料具有良好的稳定性和低背景荧光，并且可以与其他具有一致波长的荧光染料一起用于单通道激发和多通道检测 。 该染料可用于蛋白质标记和检测，荧光免疫测定和活细胞选择性成像等领域。

    Fluorescent dyes, methods of synthesis and applications thereof
    3.
    发明授权
    Fluorescent dyes, methods of synthesis and applications thereof 有权
    荧光染料，合成方法及其应用

    公开(公告)号：US08298766B2

    公开(公告)日：2012-10-30

    申请号：US13119752

    申请日：2010-04-30

    Applicant: Xiaojun Peng ,  Tong Wu ,  Jiangli Fan ,  Shiguo Sun

    Inventor： Xiaojun Peng ,  Tong Wu ,  Jiangli Fan ,  Shiguo Sun

    IPC: C12Q1/68 ,  C07D413/14 ,  C07D417/06 ,  C07D421/06

    CPC classification number: C09B23/06 ,  C07D401/06 ,  C07D413/06 ,  C07D417/06 ,  C07D421/06 ,  C09K11/06 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1037 ,  C09K2211/104 ,  G01N33/52

    Abstract: The present invention provides a category of cyanine dyes having the following general structural Formula I, wherein X is defined as C(CH3)2, O, S or Se; m is an integer from 1 to 18, R1 and R2 are each independently chosen from H, C1-18alkyl, OR7, C1-6alkyl-OR7 or halogen; R3 is pyrrolyl, imidazolyl, piperidinyl, piperazinyl, morpholinyl, guanidino, NHR5 or N(R6)2; R4 is C1-18alkyl, benzyl or (CH2)mR3; R5 is saturated and/or unsaturated, straight-chained and/or branched-chained C1-18alkyl, hydroxy alkyl, mercapto-alkyl, amino alkyl, acyl, phenyl, naphthyl or benzyl; R6 is a C2-18alkyl; R7 is H or a C1-18alkyl; Y− is an anion. The mentioned compounds can be applied to staining biological samples, to the fields of nucleic acids labeling, blood cell analysis, clinical diagnosis, immunological assays and etc.

    Abstract translation: 本发明提供了一类具有以下通式结构式I的花青染料，其中X定义为C（CH3）2，O，S或Se; m是1至18的整数，R 1和R 2各自独立地选自H，C 1-18烷基，OR 7，C 1-6烷基-OR 7或卤素; R3是吡咯基，咪唑基，哌啶基，哌嗪基，吗啉基，胍基，NHR5或N（R6）2; R4是C1-18烷基，苄基或（CH2）mR3; R5是饱和和/或不饱和的直链和/或支链C 1-18烷基，羟基烷基，巯基 - 烷基，氨基烷基，酰基，苯基，萘基或苄基; R6是C2-18烷基; R7是H或C1-18烷基; Y-是阴离子。 所提及的化合物可用于染色生物样品，核酸标记领域，血细胞分析，临床诊断，免疫测定等。

    Pentamethine cyanine fluorescent dye with N-substituting at β-position of conjugated chain
    5.
    发明授权
    Pentamethine cyanine fluorescent dye with N-substituting at β-position of conjugated chain 有权
    Pentamethine花青荧光染料，在共轭链的位置取代

    公开(公告)号：US08735601B2

    公开(公告)日：2014-05-27

    申请号：US13521046

    申请日：2010-12-06

    Applicant: Xiaojun Peng ,  Zhigang Yang ,  Fengling Song ,  Yanxia He ,  Shiguo Sun ,  Jiangli Fan

    Inventor： Xiaojun Peng ,  Zhigang Yang ,  Fengling Song ,  Yanxia He ,  Shiguo Sun ,  Jiangli Fan

    IPC: C07D209/02

    CPC classification number: C07D403/06 ,  C09B23/0016 ,  C09B23/0041 ,  C09B23/083 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  G01N2021/6439

    Abstract: A pentamethine cyanine fluorescent dye with N-substituting at β-position of conjugated chain is disclosed. The dye reacts with biosubstrate including protein, liposome and DNA, and shows excellent selectivity. It has good living cell membrane permeability and shows good selectivity in living cell staining In addition, the dye has good stability and low background fluorescence, and can be used together with other fluorescent dyes having consistent wavelengths for single-channel excitation and multi-channel detection. The dye can be used in the fields of protein labeling and detecting, fluorescence immunoassay and living cell selective imaging and the like.

    Abstract translation: 公开了在共轭链的位置上具有N取代的五甲代花青荧光染料。 染料与包括蛋白质，脂质体和DNA在内的生物底物反应，显示出优异的选择性。 它具有良好的活细胞膜渗透性，并且在活细胞染色中表现出良好的选择性。此外，染料具有良好的稳定性和低背景荧光，并且可以与其他具有一致波长的荧光染料一起用于单通道激发和多通道检测 。 该染料可用于蛋白质标记和检测，荧光免疫测定和活细胞选择性成像等领域。

    Weather-resistant dye and use thereof
    6.
    发明授权
    Weather-resistant dye and use thereof 有权
    耐候性染料及其用途

    公开(公告)号：US08591641B2

    公开(公告)日：2013-11-26

    申请号：US12992247

    申请日：2009-04-30

    Applicant: Xiaojun Peng ,  Jianzhou Zhang ,  Fan Jiangli ,  Shiguo Sun ,  Rong Zhang

    Inventor： Xiaojun Peng ,  Jianzhou Zhang ,  Fan Jiangli ,  Shiguo Sun ,  Rong Zhang

    IPC: C09D11/02 ,  C09B47/04

    CPC classification number: C09B47/26 ,  C09B62/10 ,  C09B67/0035 ,  C09D11/328

    Abstract: The invention is related to a weather-resistant dye and use thereof, which contains in molecules thereof not only chromophoric parent D, but also electron-accepting group Q which is linked with dye parent D through non-conjugated carbon link L to constitute D-L-Q dye molecule; the electron-accepting group Q has such a HOMO energy level that is lower than the HOMO energy level of the dye chromophoric parent D. The dye has sun-resistance and anti-ozone performances, which can be used as colorant in the ink, dope, lacquer, toner powder for laser printing, marker, paper, fabric, glass, porcelain or polymer.

    Abstract translation: 本发明涉及耐候性染料及其用途，其分子中不仅含有发色母体D，而且还包含与染料母体D通过非共轭碳链L连接构成DLQ染料的电子接受基团Q 分子; 电子接受基团Q具有低于染料发色母体D的HOMO能级的HOMO能级。该染料具有防晒和抗臭氧性能，可用作油墨中的着色剂，涂料 ，漆，激光打印用墨粉，标记，纸，织物，玻璃，瓷或聚合物。

    PENTAMETHINE CYANINE FLUORESCENT DYES, PREPARATION METHODS AND USES THEREOF
    7.
    发明申请
    PENTAMETHINE CYANINE FLUORESCENT DYES, PREPARATION METHODS AND USES THEREOF 有权
    戊胺衍生物荧光染料，其制备方法及其用途

    公开(公告)号：US20130309715A1

    公开(公告)日：2013-11-21

    申请号：US13982089

    申请日：2011-01-31

    Applicant: Xiaojun Peng ,  Zhigang Yang ,  Yanxia He ,  Jingyun Wang ,  Jiangli Fan ,  Shiguo Sun ,  Fengling Song

    Inventor： Xiaojun Peng ,  Zhigang Yang ,  Yanxia He ,  Jingyun Wang ,  Jiangli Fan ,  Shiguo Sun ,  Fengling Song

    IPC: G01N33/52

    CPC classification number: G01N33/52 ,  C07D403/06 ,  C09B23/0008 ,  C09B23/005 ,  C09B23/0058 ,  C09B23/08

    Abstract: A pentamethine cyanine fluorescent dye having the general formula I, a synthetic method and a use thereof are disclosed. In the general formula, X is CHO or CHCR3R4; R1 and R2 are independently selected from the group consisting of (CH2)nR2 and et al.; R3 and R4 are independently selected from the group consisting of CN, COOH and COOR16; R5, R6 and R7 are independently selected from the group consisting of H, SO3R10 and COOR11; R8 is H or C1-18 alkyl; R9 is H or CH3; R10 is N(R12R13R14R15); R11 is C1-18 alkyl; R12, R13, R14, R15 and R16 are independently selected from the group consisting of H, C1-18 alkyl, (CH2)mOR8 and (CHR9CH2O)pR8; Y− is halogen anion or OTs−; and n, m and p are integers of 0-18. The dye can be utilized to sensitively detect viscosity of micro-environment such as tissues and cells.

    Abstract translation: 公开了具有通式I的合成方法及其用途的五甲代花青荧光染料。 在通式中，X是CHO或CHCR3R4; R 1和R 2独立地选自（CH 2）n R 2等。 R3和R4独立地选自CN，COOH和COOR16; R5，R6和R7独立地选自H，SO3R10和COOR11; R8是H或C1-18烷基; R9为H或CH3; R10为N（R12R13R14R15）; R11为C1-18烷基; R 12，R 13，R 14，R 15和R 16独立地选自H，C 1-18烷基，（CH 2）mOR 8和（CHR 9 CH 2 O）p R 8; Y-是卤素阴离子或OTs-; 并且n，m和p是0-18的整数。 染料可用于敏感地检测微环境如组织和细胞的粘度。

    FLUORESCENT DYES,METHODS OF SYNTHESIS AND APPLICATIONS THEREOF
    8.
    发明申请
    FLUORESCENT DYES,METHODS OF SYNTHESIS AND APPLICATIONS THEREOF 有权
    荧光染料，合成方法及其应用

    公开(公告)号：US20110262904A1

    公开(公告)日：2011-10-27

    申请号：US13119752

    申请日：2010-04-30

    Applicant: Xiaojun Peng ,  Tong Wu ,  Jiangli Fan ,  Shiguo Sun

    Inventor： Xiaojun Peng ,  Tong Wu ,  Jiangli Fan ,  Shiguo Sun

    IPC: C12Q1/68 ,  C07D413/14 ,  C07D421/06 ,  C07D417/06

    CPC classification number: C09B23/06 ,  C07D401/06 ,  C07D413/06 ,  C07D417/06 ,  C07D421/06 ,  C09K11/06 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1037 ,  C09K2211/104 ,  G01N33/52

    Abstract: The present invention provides a category of cyanine dyes having the following general structural Formula I, wherein X is defined as C(CH3)2, O, S or Se; m is an integer from 1 to 18, R1 and R2 are each independently chosen from H, C1-18alkyl, OR7, C1-6alkyl-OR7 or halogen; R3 is pyrrolyl, imidazolyl, piperidinyl, piperazinyl, morpholinyl, guanidino, NHR5 or N(R6)2; R4 is C1-18alkyl, benzyl or (CH2)mR3; R5 is saturated and/or unsaturated, straight-chained and/or branched-chained C1-18alkyl, hydroxy alkyl, mercapto-alkyl, amino alkyl, acyl, phenyl, naphthyl or benzyl; R6 is a C2-18alkyl; R7 is H or a C1-18alkyl; Y− is an anion. The mentioned compounds can be applied to staining biological samples, to the fields of nucleic acids labeling, blood cell analysis, clinical diagnosis, immunological assays and etc.

    Abstract translation: 本发明提供了一类具有以下通式结构式I的花青染料，其中X定义为C（CH3）2，O，S或Se; m是1至18的整数，R 1和R 2各自独立地选自H，C 1-18烷基，OR 7，C 1-6烷基-OR 7或卤素; R3是吡咯基，咪唑基，哌啶基，哌嗪基，吗啉基，胍基，NHR5或N（R6）2; R4是C1-18烷基，苄基或（CH2）mR3; R5是饱和和/或不饱和的直链和/或支链C 1-18烷基，羟基烷基，巯基 - 烷基，氨基烷基，酰基，苯基，萘基或苄基; R6是C2-18烷基; R7是H或C1-18烷基; Y-是阴离子。 所提及的化合物可用于染色生物样品，核酸标记领域，血细胞分析，临床诊断，免疫测定等。

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