The various embodiments provide methods implemented in a MSMA communication device for managing a victim subscription's de-sense by proactively implementing an RF coexistence management strategy on the victim subscription when an RF coexistence event starts. In various embodiments, a MSMA communication device may implement an RF coexistence management strategy by determining when an aggressor subscription will de-sense a victim subscription and configuring the victim to anticipate and mitigate de-sense during the aggressor's transmissions. Thus, the various embodiments may provide dramatic improvements to the victim's overall reception performance and overall user experience.