A multi-sensor control circuit used in an electronic cigarette comprises a control module, at least two inhalation sensors, and at least two unidirectional circuits corresponding to the inhalation sensors. An output terminal of each inhalation sensor is connected to an input terminal of a corresponding unidirectional circuit, and output terminals of the unidirectional circuits are all connected to a same input pin of the control module. Each inhalation sensor outputs a sensing voltage signal to the corresponding one of the unidirectional circuits upon sensing airflow. Each unidirectional circuit filters the sensing voltage signal received from a corresponding inhalation sensor to generate a unidirectional voltage signal, and outputs the unidirectional voltage signal to the input pin of the control module. The control module controls the electronic cigarette to work upon receiving the unidirectional voltage signal outputted from any unidirectional circuit.