发明申请
US20150087632A1 CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINES DERIVATIVES AS JAK INHIBITORS
审中-公开
作为JAK抑制剂的环己基取代的吡咯并吡啶衍生物和衍生物衍生物
- 专利标题： CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINES DERIVATIVES AS JAK INHIBITORS
- 专利标题（中）： 作为JAK抑制剂的环己基取代的吡咯并吡啶衍生物和衍生物衍生物
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申请号： US14556775申请日： 2014-12-01
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公开(公告)号： US20150087632A1公开(公告)日： 2015-03-26
- 发明人: James D. Rodgers , Stacey Shepard , Wenyu Zhu , Lixin Shao , Joseph Glenn
- 申请人： Incyte Corporation
- 申请人地址： US DE Wilmington
- 专利权人： INCYTE CORPORATION
- 当前专利权人： INCYTE CORPORATION
- 当前专利权人地址： US DE Wilmington
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D471/04
摘要：
The present invention provides cyclobutyl substituted pyrrolopyrimidines and pyrrolopyridines of Formula I: wherein X, Y, Z, L, A, R5, n and m are defined above, as well as their compositions and methods of use, that modulate the activity of Janus kinases (JAKs) and are useful in the treatment of diseases related to the activity of JAKs including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
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