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![Salts of the Janus Kinase Inhibitor (R)-3-(4-(7h-Pyrrolo[2,3-D]Pyrimidin-4-YL)-1h-Pyrazol-1-Yl)-3- Cyclopentylpropanenitrile](/abs-image/US/2022/09/15/US20220288078A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220288078A1
公开(公告)日：2022-09-15
申请号：US17536925
申请日：2021-11-29
发明人： Hui-Yin Li , James D. Rodgers
IPC分类号： A61K31/519 , A61P17/12 , A61P17/06 , A61P17/08 , C07D487/04 , A61K9/00 , A61K9/20
摘要： The present invention provides salt forms of (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile that are useful in the modulation of Janus kinase activity and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
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![Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors](/abs-image/US/2022/05/17/US11331320B2/abs.jpg.150x150.jpg)
公开(公告)号：US11331320B2
公开(公告)日：2022-05-17
申请号：US16821624
申请日：2020-03-17
发明人： James D. Rodgers , Stacey Shepard
IPC分类号： A61K31/519 , A61P29/00 , A61P35/04 , C07D471/04 , C07D487/04 , C07D417/04 , A61K31/573 , A61K45/06 , A61P17/04 , A61K9/00 , A61K9/20 , C07B59/00
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
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公开(公告)号：US20200002341A1
公开(公告)日：2020-01-02
申请号：US16436195
申请日：2019-06-10
发明人： Jiacheng Zhou , James D. Rodgers , Haisheng Wang
IPC分类号： C07D487/04 , C07F7/18 , C07F7/10 , C07F5/02 , C07F7/08
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
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![Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors](/abs-image/US/2017/05/30/US09662335B2/abs.jpg.150x150.jpg)
公开(公告)号：US09662335B2
公开(公告)日：2017-05-30
申请号：US15173057
申请日：2016-06-03
申请人： Incyte Corporation
发明人： James D. Rodgers , Stacey Shepard
IPC分类号： C07D487/04 , A61K31/519 , C07D471/04 , A61K45/06 , C07D417/04 , C07B59/00 , A61K9/00 , A61K9/20 , A61K31/573 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
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![Heteroaryl Substituted Pyrrolo[2,3-B] Pyridines And Pyrrolo[2,3-B] Pyrimidines As Janus Kinase Inhibitors](/abs-image/US/2017/03/16/US20170071947A1/abs.jpg.150x150.jpg)
5.发明申请Heteroaryl Substituted Pyrrolo[2,3-B] Pyridines And Pyrrolo[2,3-B] Pyrimidines As Janus Kinase Inhibitors 有权杂芳基取代的吡咯并[2,3-B]吡啶和吡咯并[2,3-B]嘧啶作为Janus激酶抑制剂公开(公告)号：US20170071947A1
公开(公告)日：2017-03-16
申请号：US15356957
申请日：2016-11-21
发明人： James D. Rodgers , Stacey Shepard
IPC分类号： A61K31/519 , A61K31/573 , A61K9/00
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供调节Janus激酶活性的杂芳基取代的吡咯并[2,3-b]吡啶和杂芳基取代的吡咯并[2,3-b]嘧啶，可用于治疗与Janus激酶活性有关的疾病， 例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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![Heteroaryl Substituted Pyrrolo[2,3-B] Pyridines And Pyrrolo[2,3-B] Pyrimidines As Janus Kinase Inhibitors](/abs-image/US/2016/12/01/US20160346286A1/abs.jpg.150x150.jpg)
公开(公告)号：US20160346286A1
公开(公告)日：2016-12-01
申请号：US15233652
申请日：2016-08-10
发明人： James D. Rodgers , Stacey Shepard
IPC分类号： A61K31/519 , A61K9/20 , A61K9/00 , A61K45/06 , A61K31/573
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
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公开(公告)号：US20160046650A1
公开(公告)日：2016-02-18
申请号：US14923105
申请日：2015-10-26
IPC分类号： C07D498/06 , C07D519/00
CPC分类号： C07D498/06 , C07D471/06 , C07D498/16 , C07D519/00
摘要： The present invention relates to tricyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.
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![Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as Janus kinase](/abs-image/US/2015/12/08/US09206187B2/abs.jpg.150x150.jpg)
8.发明授权Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as Janus kinase 有权杂芳基取代的吡咯并[2,3-B]吡啶和吡咯并[2,3-b]嘧啶作为Janus激酶公开(公告)号：US09206187B2
公开(公告)日：2015-12-08
申请号：US14020505
申请日：2013-09-06
IPC分类号： A61K31/519 , C07D487/04 , C07D471/04 , A61K45/06 , A61K31/437
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供调节Janus激酶活性的杂芳基取代的吡咯并[2,3-b]吡啶和杂芳基取代的吡咯并[2,3-b]嘧啶，可用于治疗与Janus激酶活性有关的疾病， 例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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公开(公告)号：US20150175604A1
公开(公告)日：2015-06-25
申请号：US14575284
申请日：2014-12-18
申请人： Incyte Corporation
发明人： James D. Rodgers , Stacey Shepard , Haisheng Wang , Lixin Shao
IPC分类号： C07D471/14
CPC分类号： C07D471/14 , A61K31/437
摘要： The present invention relates to tricyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.
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![Heteroaryl substituted pyrrolo[2,3-B]pyridines and pyrrolo[2,3-B]pyrimidines as Janus kinase inhibitors](/abs-image/US/2015/01/13/US08933086B2/abs.jpg.150x150.jpg)
10.发明授权Heteroaryl substituted pyrrolo[2,3-B]pyridines and pyrrolo[2,3-B]pyrimidines as Janus kinase inhibitors 有权杂芳基取代的吡咯并[2,3-B]吡啶和吡咯并[2,3-b]嘧啶作为Janus激酶抑制剂公开(公告)号：US08933086B2
公开(公告)日：2015-01-13
申请号：US14033039
申请日：2013-09-20
申请人： Incyte Corporation
IPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , C07D471/04 , A61P35/00
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供调节Janus激酶活性的杂芳基取代的吡咯并[2,3-b]吡啶和杂芳基取代的吡咯并[2,3-b]嘧啶，可用于治疗与Janus激酶活性有关的疾病， 例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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