发明申请
- 专利标题： RIBONUCLEOTIDE REDUCTASE INHIBITORS AND METHODS OF USE
- 专利标题（中）： RIBONUCLEOTIDE还原抑制剂及其使用方法
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申请号： US14444172申请日： 2014-07-28
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公开(公告)号： US20150087844A1公开(公告)日： 2015-03-26
- 发明人: David Horne , Christopher Lincoln
- 申请人： City of Hope
- 主分类号： C07D277/46
- IPC分类号： C07D277/46 ; C07D277/40 ; C07C45/68
摘要：
Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme, as well as methods of synthesizing these novel compounds. The compounds may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.
公开/授权文献
- US09126960B2 Ribonucleotide reductase inhibitors and methods of use 公开/授权日：2015-09-08
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