公开(公告)号：US20240343682A1

公开(公告)日：2024-10-17

申请号：US18755058

申请日：2024-06-26

申请人： City of Hope

发明人： Linda H. Malkas ,  David Horne ,  Robert J. Hickey ,  Long Gu

IPC分类号： C07C233/76 ,  A61K31/167 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4725 ,  A61K33/243 ,  A61P35/00 ,  A61P35/02 ,  C07C237/22 ,  C07D213/68 ,  C07D217/26 ,  C07D401/12

CPC分类号： C07C233/76 ,  A61K31/167 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4725 ,  A61K33/243 ,  A61P35/00 ,  A61P35/02 ,  C07C237/22 ,  C07D213/68 ,  C07D217/26 ,  C07D401/12

摘要： Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.

公开(公告)号：US20240325451A1

公开(公告)日：2024-10-03

申请号：US18622589

申请日：2024-03-29

申请人： CITY OF HOPE

发明人： Defu ZENG

IPC分类号： A61K35/28 ,  A61K31/675 ,  A61K31/7056 ,  A61K35/12 ,  A61K35/26 ,  A61K39/395 ,  A61L27/36 ,  A61L27/54 ,  A61P37/06

CPC分类号： A61K35/28 ,  A61K31/675 ,  A61K31/7056 ,  A61K35/26 ,  A61K39/39541 ,  A61L27/3604 ,  A61L27/54 ,  A61P37/06 ,  A61K2035/122 ,  A61K2035/124

摘要： Described herein are methods and transplant compositions for promoting or inducing organ transplant tolerance and/or immune tolerance by conditioning a recipient with radiation-free, low-doses of cyclophosphamide (CY), pentostatin (PT), and anti-thymocyte globulin (ATG) prior to transplantation of PD-L1+ donor-derived CD4+ T-depleted bone marrow cells. In certain embodiments, the methods may also include transplanting an organ, such as a solid organ, into the recipient. The transplant compositions may comprise a therapeutically effective amount of PD-L1+ donor-derived CD4+ T-depleted bone marrow cells and a donor organ.

公开(公告)号：US12060435B2

公开(公告)日：2024-08-13

申请号：US16959981

申请日：2019-01-07

申请人： CITY OF HOPE

发明人： John C. Williams ,  Jeremy King

IPC分类号： C07K16/18 ,  A61K47/65 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  C12N5/0783

CPC分类号： C07K16/32 ,  A61K47/65 ,  A61P35/00 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/283 ,  C07K16/2866 ,  C07K16/2875 ,  C07K16/2878 ,  C07K16/2887 ,  C07K16/3092 ,  C12N5/0636 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/569 ,  C07K2317/64

摘要： Provided herein are, inter alia, novel peptide compositions having multi-specific binding capabilities useful for therapeutic and diagnostic purposes. The peptide compositions provided herein are polypeptide conjugates including at least two ligand binding domains able to target (bind) two or more ligands (e.g., antigens) at the same time. The peptide compositions provided herein can be produced at very high yields and are therefore easy to manufacture.

公开(公告)号：US12054447B2

公开(公告)日：2024-08-06

申请号：US17730948

申请日：2022-04-27

申请人： City of Hope

发明人： Linda H. Malkas ,  David Horne ,  Robert J. Hickey ,  Long Gu

IPC分类号： C07C233/76 ,  A61K31/167 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4725 ,  A61K33/243 ,  A61P35/00 ,  A61P35/02 ,  C07C237/22 ,  C07D213/68 ,  C07D217/26 ,  C07D401/12

CPC分类号： C07C233/76 ,  A61K31/167 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4725 ,  A61K33/243 ,  A61P35/00 ,  A61P35/02 ,  C07C237/22 ,  C07D213/68 ,  C07D217/26 ,  C07D401/12 ,  A61K33/24 ,  A61K2300/00 ,  A61K31/4725 ,  A61K2300/00 ,  A61K31/4418 ,  A61K2300/00

摘要： Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.

公开(公告)号：US12043673B2

公开(公告)日：2024-07-23

申请号：US17503132

申请日：2021-10-15

申请人： City of Hope

发明人： John E. Shively ,  Lin Li ,  Maciej Kujawski ,  Piotr Swiderski

IPC分类号： C07K16/00 ,  C07K16/28 ,  C07K16/42 ,  C07K16/46 ,  C07K19/00

CPC分类号： C07K16/4283 ,  C07K16/283 ,  C07K16/2878 ,  C07K16/46 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/52

摘要： The compositions and methods provide herein include, inter alia, antibodies attached to single-stranded oligoribonucleotides. Two antibodies are capable of forming complexes in vivo through hybridization of the respective complementary oligoribonucleotides they are bound to. For example, a first antibody bound to a first oligoribonucleotide through a first chemical linker may be administered to a subject, bind to a cell surface antigen in vivo and subsequently form an antibody complex in vivo with a second antibody bound to a second oligoribonucleotide through a second chemical linker, through complementary base-pairing between the first and the second oligoribonucleotide. The compositions and methods provided herein are, inter alia, useful for diagnostic and therapeutic purposes, for example, the treatment of cancer or autoimmune disease.

公开(公告)号：US20240229034A1

公开(公告)日：2024-07-11

申请号：US18285964

申请日：2022-04-06

申请人： City of Hope

发明人： Kevin Morris ,  Alicia Davis ,  Tristan Scott ,  Roslyn Ray ,  Denis O'Meally

IPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K47/69

CPC分类号： C12N15/1131 ,  A61K31/7105 ,  A61K47/6925 ,  C12N2310/14

摘要： Provided herein are, inter alia, lipid nanoparticles, lipid nanoparticles comprising nucleic acids encapsulated therein, pharmaceutical compositions comprising lipid nanoparticles which comprise nucleic acids encapsulated therein, and methods of treating diseases, such as coronavirus infections (e.g., SARS-CoV-2, SARS-CoV-2, MERS-CoV), COVID, and MERS.

公开(公告)号：US20240226283A9

公开(公告)日：2024-07-11

申请号：US18032052

申请日：2021-10-15

申请人： CITY OF HOPE

发明人： Don J. DIAMOND ,  Corinna LA ROSA

IPC分类号： A61K39/245 ,  A61K39/295 ,  C12N15/86

CPC分类号： A61K39/245 ,  A61K39/295 ,  C12N15/86 ,  A61K2039/5256

摘要： Disclosed is a method of treating or preventing a CMV infection in a recipient of a hematopoietic cell transplant (HCT). The method entails administering an effective amount of a CMV Triplex vaccine composition to a donor and/or recipient of the hematopoietic cells.

公开(公告)号：US20240156928A1

公开(公告)日：2024-05-16

申请号：US18424395

申请日：2024-01-26

申请人： City of Hope

发明人： Xiuli Wang ,  Stephen J. Forman ,  Don J. Diamond

IPC分类号： A61K39/00 ,  A61K35/17 ,  A61K39/12 ,  A61K39/17 ,  A61K39/245 ,  A61P35/00 ,  C07K14/705 ,  C07K14/71 ,  C07K14/725 ,  C07K16/28 ,  C12N5/0783

CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K39/12 ,  A61K39/17 ,  A61K39/245 ,  A61P35/00 ,  C07K14/70503 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/71 ,  C07K16/2803 ,  C07K16/2833 ,  C12N5/0636 ,  C12N5/0637 ,  C12N5/0638 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61K2039/585 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/03 ,  C12N2501/998 ,  C12N2710/16134

摘要： T cells expressing a chimeric antigen receptor and a T cell receptor specific for CMV (bi-specific T cells) are described as a methods for using such cells in immunotherapy. In the immunotherapy methods, the recipient can be exposed to a CMV vaccine in order to expand and/or stimulate the be-specific T cells.

公开(公告)号：US11980629B2

公开(公告)日：2024-05-14

申请号：US17399871

申请日：2021-08-11

申请人： CITY OF HOPE

发明人： Defu Zeng

IPC分类号： A61K31/675 ,  A61K31/7056 ,  A61K35/14 ,  A61K35/17 ,  A61K35/26 ,  A61K35/28 ,  A61K39/395 ,  A61P37/06 ,  C07K16/28

CPC分类号： A61K31/675 ,  A61K31/7056 ,  A61K35/14 ,  A61K35/17 ,  A61K35/26 ,  A61K35/28 ,  A61K39/39516 ,  A61P37/06 ,  C07K16/2809 ,  A01K2207/20 ,  A01K2227/105 ,  A01K2267/0387 ,  A61K31/7056 ,  A61K2300/00 ,  A61K31/675 ,  A61K2300/00

摘要： Disclosed herein are conditioning regimens and methods for inducing MHC- or HLA-mismatched mixed chimerism by conditioning a recipient with radiation-free, low-doses of cyclophosphamide (CY), pentostatin (PT), and anti-thymocyte globulin (ATG) prior to transplantation of donor bone marrow cells. In certain embodiments, the donor bone marrow cells may be CD4+ T-depleted bone marrow cells. The conditioning regimens and methods may also include administering one or more populations of conditioning donor cells selected from donor CD4+ T-depleted spleen cells, donor CD8+ T cells, and donor G-CSF-mobilized peripheral blood mononuclear cells. The conditioning regimen is clinically acceptable and can be used for treating hereditary hematological diseases and autoimmune diseases, as well as for promoting organ transplantation immune tolerance.

公开(公告)号：US11974993B2

公开(公告)日：2024-05-07

申请号：US17677408

申请日：2022-02-22

申请人： City of Hope

发明人： Yuelong Ma ,  Rajiv Nallu ,  David Horne

IPC分类号： A61K31/4439 ,  A61K9/08 ,  A61K47/44

CPC分类号： A61K31/4439 ,  A61K9/08 ,  A61K47/44

摘要： Provided herein are solution formulations of CX-011 and related methods for making solution formulations of CX-011. Also provided are methods of treating an inflammatory disorder, such as osteoarthritis, or cancer in a subject in need thereof by administering an effective amount of the solution formulations of CX-011.