A smart card connection circuit of an electronic device which includes a card holder, a travel switch, and a switching unit; a contact of the travel switch is located in the card holder, and an output end of the travel switch is connected to a control end of the switching unit; and when a smart card at a preset position in the card holder leaves the preset position, the smart card leaves the contact of the travel switch, the travel switch controls the switching unit to switch to a second output end, and each signal cable pin on the card holder is grounded by using the switching unit before a power cable pin on the card holder is grounded by using the switching unit. The present invention is applied to electronic devices such as a mobile phone and a tablet computer.