Invention Application
US20150094450A1 REPEBODY FOR NOVEL INTERLEUKIN-6 AND USE THEREOF
有权
REPLEBODY FOR NOVEL INTERLEUKIN-6及其使用
- Patent Title: REPEBODY FOR NOVEL INTERLEUKIN-6 AND USE THEREOF
- Patent Title (中): REPLEBODY FOR NOVEL INTERLEUKIN-6及其使用
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Application No.: US14381407Application Date: 2013-02-27
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Publication No.: US20150094450A1Publication Date: 2015-04-02
- Inventor: Hak-Sung Kim , Joong-Jae Lee , Jung Min Choi , Eun-Kyeong Jo , Chul-Su Yang , Hae-Kap Cheong , Hyun Jung Kim
- Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY , THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC) , KOREA BASIC SCIENCE INSTITUTE
- Applicant Address: KR Daejeon KR Daejeon KR Daejeon
- Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY,THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC),KOREA BASIC SCIENCE INSTITUTE
- Current Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY,THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC),KOREA BASIC SCIENCE INSTITUTE
- Current Assignee Address: KR Daejeon KR Daejeon KR Daejeon
- Priority: KR10-2012-0019927 20120227; KR10-2013-0007380 20130123
- International Application: PCT/KR2013/001605 WO 20130227
- Main IPC: C07K16/24
- IPC: C07K16/24 ; C07K14/705 ; C07K14/195

Abstract:
The present invention relates to an repebody capable of binding specifically to interleukin-6 (IL-6) to inhibit the biological activity of IL-6, a polynucleotide encoding the repebody, a vector comprising the polynucleotide, a recombinant microorganism having introduced therein the polynucleotide or the vector, a method of producing the repebody using the recombinant microorganism, a composition for preventing or treating cancer, which comprises the repebody, and a method for preventing or treating cancer, which comprises administering the composition for preventing or treating cancer, which comprises the repebody. The repebody of the present invention significantly reduces the activity of STAT3 and the concentration of interleukin-6, and thus can be widely used as an agent for preventing or treating IL-6-related diseases.
Public/Granted literature
- US10017570B2 Repebody for novel interleukin-6 and use thereof Public/Granted day:2018-07-10
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