Invention Application
US20150099881A1 PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS
有权
制备羟基环戊二烯基咪唑化合物的方法
- Patent Title: PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS
- Patent Title (中): 制备羟基环戊二烯基咪唑化合物的方法
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Application No.: US14401091Application Date: 2013-05-17
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Publication No.: US20150099881A1Publication Date: 2015-04-09
- Inventor: Jonathan W. Lane , Travis Remarchuk , Sagar Shakya , Keith L. Spencer , Peter J. Stengel
- Applicant: Array BioPharma Inc. , Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genetech, Inc.
- Current Assignee: Genetech, Inc.
- Current Assignee Address: US CA South San Francisco
- International Application: PCT/US2013/041624 WO 20130517
- Main IPC: C07D239/70
- IPC: C07D239/70 ; C07D239/42
Abstract:
The invention provides new processes for making and purifying hydroxylated cyclopenta[d]pyrimidine compounds, which are useful for the treatment of diseases such as cancer as AKT protein kinase inhibitors, including the compound (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.
Public/Granted literature
- US09309204B2 Process for making hydroxylated cyclopentylpyrimidine compounds Public/Granted day:2016-04-12
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