Systems and methods for multi-channel signal processing by virtue of packet-based time-slicing with single processing core logic. The processing core logic is configured to receive data streams from the multiple communication channels at a data processing unit, and process data fragments of the data streams in a time-sliced manner. The processing core logic can switch from processing a first data fragment of a first data stream to processing a first data fragment of a second data stream at an end of a time slice, wherein the time slice is determined by a fragment boundary associated with the data fragment of the first data stream.