The invention provides a composition for anti-medicine wrinkle relief, characterized in that said composition comprises the following composition of raw materials in parts by weight: 10-15 parts of water, 5-6 parts of collagen, silk, hydrolyzed 3-5 parts of collagen, milk protein 2-6 copies, copies of the product of yeast fermentation filtrate 3-5, 2-3 parts sucrose laurate, 4-6 parts oil of roses, chrysanthemum extract thousand Days 2-4 parts 3-6 parts of Salvia flower extract, collagen amino acids 3-5 parts, 1-2 parts frankincense extract, yeast peptide 3-4, 2-3 parts carbomer, 2-4 parts of mother of pearl extract, Ganoderma lucidum extract 3-5 parts. The composition can quickly penetrate the cortex, the absorption of various active ingredients depth help rebuild the skin matrix, abundance of skin firmness, smooth wrinkles, and texture.