发明申请
- 专利标题: Phospholinked Dye Analogs with an Amino Acid Linker
- 专利标题(中): 磷酸染料类似物与氨基酸接头
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申请号: US14667869申请日: 2015-03-25
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公开(公告)号: US20150197794A1公开(公告)日: 2015-07-16
- 发明人: Gene SHEN
- 申请人: Pacific Biosciences of California, Inc.
- 申请人地址: US CA Menlo Park
- 专利权人: Pacific Biosciences of California, Inc.
- 当前专利权人: Pacific Biosciences of California, Inc.
- 当前专利权人地址: US CA Menlo Park
- 主分类号: C12Q1/68
- IPC分类号: C12Q1/68 ; C07K5/09 ; C07K5/11 ; C07H19/10
摘要:
In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention.
公开/授权文献
- US09499862B2 Phospholinked dye analogs with an amino acid linker 公开/授权日:2016-11-22