发明申请
- 专利标题： DIFFERENTIATION MARKER AND DIFFERENTIATION CONTROL OF EYE CELL
- 专利标题（中）： 眼细胞分化标记和差异控制
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申请号： US14413066申请日： 2013-07-03
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公开(公告)号： US20150202256A1公开(公告)日： 2015-07-23
- 发明人: Takahiro Nakamura , Noriko Koizumi , Naoki Okumura , Shigeru Kinoshita , Kana Tominaga , Satoshi Kawasaki
- 申请人： Kyoto Prefectural Public University Corporation , The Doshisha , Senju Pharmaceutical Co., Ltd.
- 申请人地址： JP Kamigyo-ku, Kyoto-shi, Kyoto JP Osaka-shi, Osaka JP Kamigyo-ku, Kyoto-shi, Kyoto
- 专利权人： Kyoto Prefectural Public University Corporation,Senju Pharmaceutical Co., Ltd.,The Doshisha
- 当前专利权人： Kyoto Prefectural Public University Corporation,Senju Pharmaceutical Co., Ltd.,The Doshisha
- 当前专利权人地址： JP Kamigyo-ku, Kyoto-shi, Kyoto JP Osaka-shi, Osaka JP Kamigyo-ku, Kyoto-shi, Kyoto
- 优先权： JP2012-152960 20120706; JP2013-016848 20130131
- 国际申请： PCT/JP2013/068802 WO 20130703
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; A61K35/30 ; C12N5/079
摘要：
The present invention relates to a differentiation marker and a differentiation controlling technique for an eye cell. More particularly, the present invention has attained an object of providing a differentiation marker for an eye cell among the aforementioned problems, by providing a marker for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, the marker comprising GPR49/LGR5, as well as a detection agent or detection method for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, comprising a substance binding to GPR49/LGR5. In addition, the present invention has attained an object of providing a differentiation controlling technique for an eye cell, by providing an agent for suppressing differentiation and/or promoting proliferation of an eye cell, comprising R-spondins.