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    DIFFERENTIATION MARKER AND DIFFERENTIATION CONTROL OF EYE CELL
    1.
    发明申请
    DIFFERENTIATION MARKER AND DIFFERENTIATION CONTROL OF EYE CELL 有权
    眼细胞分化标记和差异控制

    公开(公告)号：US20150202256A1

    公开(公告)日：2015-07-23

    申请号：US14413066

    申请日：2013-07-03

    申请人： Kyoto Prefectural Public University Corporation ,  The Doshisha ,  Senju Pharmaceutical Co., Ltd.

    发明人： Takahiro Nakamura ,  Noriko Koizumi ,  Naoki Okumura ,  Shigeru Kinoshita ,  Kana Tominaga ,  Satoshi Kawasaki

    IPC分类号： A61K38/17 ,  A61K35/30 ,  C12N5/079

    CPC分类号： A61K38/1709 ,  A61K35/30 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N5/0621 ,  C12N2501/40 ,  C12N2501/415 ,  C12Q1/6881 ,  C12Q2600/158 ,  G01N33/56966 ,  G01N2333/726 ,  G01N2800/16

    摘要： The present invention relates to a differentiation marker and a differentiation controlling technique for an eye cell. More particularly, the present invention has attained an object of providing a differentiation marker for an eye cell among the aforementioned problems, by providing a marker for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, the marker comprising GPR49/LGR5, as well as a detection agent or detection method for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, comprising a substance binding to GPR49/LGR5. In addition, the present invention has attained an object of providing a differentiation controlling technique for an eye cell, by providing an agent for suppressing differentiation and/or promoting proliferation of an eye cell, comprising R-spondins.

    摘要翻译： 本发明涉及眼细胞的分化标记和分化控制技术。 更具体地，本发明通过提供用于鉴定角膜内皮细胞中具有高增殖能力的细胞和/或角膜分化能力的标记物，提供了上述问题中的眼细胞分化标记物的目的。 内皮细胞，包括GPR49 / LGR5的标记物，以及用于鉴定角膜内皮细胞中具有高增殖能力的细胞和/或角膜内皮细胞的分化能力的检测剂或检测方法，其包含与GPR49结合的物质 / LGR5。 此外，本发明通过提供用于抑制包含R-螺旋藻的眼细胞分化和/或促进增殖的试剂，已经达到了提供眼细胞分化控制技术的目的。