发明申请
- 专利标题： DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
- 专利标题（中）： DIHYDROPYRIDONE P1 AS因子XIA抑制剂
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申请号： US14419002申请日： 2013-08-02
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公开(公告)号： US20150203492A1公开(公告)日： 2015-07-23
- 发明人: Wu Yang , James R. Corte , Paul J. Gilligan , Donald J.P. Pinto , William R. Ewing , Andrew K. Dilger , Yufeng Wang , Tianan Fang , Kumar B. Pabbisetty , Leon M. Smith, II
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 国际申请： PCT/US2013/053416 WO 20130802
- 主分类号： C07D471/08
- IPC分类号： C07D471/08 ; C07D401/04 ; C07D487/08 ; C07D471/18 ; C07H17/02
摘要：
The present invention provides compounds of Formula (X): (Formula (X), or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
公开/授权文献
- US09409908B2 Dihydropyridone p1 as factor XIa inhibitors 公开/授权日：2016-08-09
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