发明申请
US20150204876A1 PROTEIN MICROARRAY FOR CHARACTERIZING THE SPECIFICITY OF THE MONOCLONAL IMMUNOGLOBULINS OF MGUS OR MYELOMA PATIENTS
有权
用于表征MGUS或MYELOMA患者单克隆免疫球蛋白特异性的蛋白微阵列
- 专利标题： PROTEIN MICROARRAY FOR CHARACTERIZING THE SPECIFICITY OF THE MONOCLONAL IMMUNOGLOBULINS OF MGUS OR MYELOMA PATIENTS
- 专利标题（中）： 用于表征MGUS或MYELOMA患者单克隆免疫球蛋白特异性的蛋白微阵列
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申请号： US14416890申请日： 2013-07-23
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公开(公告)号： US20150204876A1公开(公告)日： 2015-07-23
- 发明人: Edith Bigot-Corbel , Sylvie Hermouet , Delphine Feron , Cathy Charlier , Pierre Weigel , Adrien Herlédan , Yannick Jacques
- 申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE DE NANTES , CHU NANTES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) , UNIVERSITE D'ANGERS
- 优先权： EP12305896.8 20120723
- 国际申请： PCT/EP2013/065524 WO 20130723
- 主分类号： G01N33/577
- IPC分类号： G01N33/577 ; B01J19/00
摘要：
The present invention concerns materials and methods for characterizing monoclonal immunoglobulin specificity of a Monoclonal Gammopathy of Undetermined Significance (MGUS) or Myeloma patients using a protein microarray comprising (a) a substrate, (b) antigens immobilized on the substrate, said antigens being selected from a defined group consisting of infectious agent antigens and/or self-antigens. In particular said protein microarray may be used to improve diagnosis, for the prognosis of myeloma or MGUS, for preventing transformation of MGUS toward myeloma, for adapting treatment of MGUS and myeloma or for monitoring the response to therapy of MGUS and myeloma patients.
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