Invention Application
- Patent Title: CYTOCHROME P450 SUICIDE GENE SYSTEM
- Patent Title (中): CYTOCHROME P450 SUICIDE基因系统
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Application No.: US14404916Application Date: 2013-05-28
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Publication No.: US20150216948A1Publication Date: 2015-08-06
- Inventor: Helmut Hanenberg , Constanze Wiek , Christof Kramm , Eva Schmidt
- Applicant: Helmut Hanenberg , Constanze Wiek , Christof Kramm , Eva Schmidt
- Priority: EP12170232.8 20120531
- International Application: PCT/EP2013/060973 WO 20130528
- Main IPC: A61K38/44
- IPC: A61K38/44 ; A61K35/17 ; A61K31/341 ; C12N9/02
Abstract:
The invention relates to a modified human CYP4B1 protein and a nucleic acid encoding for the modified human CYP4B1 protein. The invention further relates to an expression vector comprising a nucleic acid encoding for a modified human CYP4B1 protein, as well as to a cell comprising a modified CYP4B1 protein. In addition, the invention relates to a modified human CYP4B1 protein for use in treating transplantation induced graft-versus-host-disease (GvHD), and to 4-ipomeanol (4-IPO) for use in killing a cell.
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