公开(公告)号：US20120141440A1

公开(公告)日：2012-06-07

申请号：US13259190

申请日：2010-03-26

Applicant: Axel Rethwilm ,  Dirk Lindemann ,  Helmut Hanenberg ,  Wade D. Clapp

Inventor： Axel Rethwilm ,  Dirk Lindemann ,  Helmut Hanenberg ,  Wade D. Clapp

IPC: A61K48/00 ,  C12N5/10 ,  A61P7/06 ,  C12N15/63

CPC classification number: C12N15/86 ,  C12N2740/17032 ,  C12N2799/021

Abstract: The disclosure of the present application provides foamyvirus vectors, as well as methods and kits involving the same. In at least one embodiment, a plurality of recombinant vectors comprises an expression sequence encoding at least one component of a foamyvirus particle, wherein at least one codon of the expression sequence is optimized for expression in homo sapiens.

Abstract translation: 本申请的公开内容提供泡沫病毒载体，以及涉及其的方法和试剂盒。 在至少一个实施方案中，多个重组载体包含编码泡沫病毒颗粒的至少一种组分的表达序列，其中表达序列的至少一个密码子被优化用于在智人中表达。

公开(公告)号：US20190161807A1

公开(公告)日：2019-05-30

申请号：US16216307

申请日：2018-12-11

Applicant: Helmut Hanenberg ,  Heinrich-Heine-Universität Düsseldorf ,  Universität zu Köln

Inventor： Helmut Hanenberg ,  Dieter Niederacher ,  Kathrin Irmgard Maria Scheckenbach ,  Rita Schmutzler ,  Alfons Meindl ,  Constanze Wiek ,  Verena Friemann ,  Marcel Freund

IPC: C12Q1/6886

Abstract: The invention discloses in vitro methods and a system for determining a predisposition of a subject for developing a cancer on the basis of analyzing a sample of the subject for an alteration of at least one allele of the RAD51C gene. Further disclosed are in vitro methods for assessing clinical features or a pathological progression of a cancer and for assessing at least one RAD51C gene alteration in a cell. In addition a kit for determining a predisposition of a subject for developing a cancer, and certain uses of oligonucleotides for determining the presence of at least one mono-allelic germ-line mutation of the RAD51C gene.

公开(公告)号：US20150216948A1

公开(公告)日：2015-08-06

申请号：US14404916

申请日：2013-05-28

Applicant: Helmut Hanenberg ,  Constanze Wiek ,  Christof Kramm ,  Eva Schmidt

Inventor： Helmut Hanenberg ,  Constanze Wiek ,  Christof Kramm ,  Eva Schmidt

IPC: A61K38/44 ,  A61K35/17 ,  A61K31/341 ,  C12N9/02

CPC classification number: A61K38/44 ,  A61K31/341 ,  A61K35/17 ,  A61K48/005 ,  C12N7/00 ,  C12N9/0071 ,  C12N9/0079 ,  C12N15/86 ,  C12N2740/17032 ,  C12N2740/17043 ,  C12N2740/17052 ,  C12N2999/007 ,  C12Y114/14001

Abstract: The invention relates to a modified human CYP4B1 protein and a nucleic acid encoding for the modified human CYP4B1 protein. The invention further relates to an expression vector comprising a nucleic acid encoding for a modified human CYP4B1 protein, as well as to a cell comprising a modified CYP4B1 protein. In addition, the invention relates to a modified human CYP4B1 protein for use in treating transplantation induced graft-versus-host-disease (GvHD), and to 4-ipomeanol (4-IPO) for use in killing a cell.

Abstract translation: 本发明涉及修饰的人CYP4B1蛋白和编码修饰的人CYP4B1蛋白的核酸。 本发明还涉及包含编码修饰的人CYP4B1蛋白的核酸以及包含修饰的CYP4B1蛋白的细胞的表达载体。 此外，本发明涉及用于治疗移植诱导的移植物抗宿主病（GvHD）的修饰的人CYP4B1蛋白，以及用于杀死细胞的4-异麦芽糖醇（4-IPO）。

公开(公告)号：US20120045771A1

公开(公告)日：2012-02-23

申请号：US13139320

申请日：2009-12-11

Applicant: Markus Beier ,  Peer F. Staehler ,  Cord F. Staehler ,  Daniel Summerer ,  Jack T. Leonard ,  Stephan Bau ,  Anthony Caruso ,  Nadine Schracke ,  Andreas Keller ,  Helmut Hanenberg ,  Olaf Eckermann

Inventor： Markus Beier ,  Peer F. Staehler ,  Cord F. Staehler ,  Daniel Summerer ,  Jack T. Leonard ,  Stephan Bau ,  Anthony Caruso ,  Nadine Schracke ,  Andreas Keller ,  Helmut Hanenberg ,  Olaf Eckermann

IPC: C12Q1/68 ,  C07H21/00 ,  C12S3/20

CPC classification number: C12Q1/6834 ,  C12N15/1006 ,  C12Q1/6806 ,  C12Q2565/518 ,  C12Q2525/191

Abstract: The invention relates to a method for isolation of target molecules from a nucleic acid population.

Abstract translation: 本发明涉及从核酸群体分离靶分子的方法。

公开(公告)号：US20150111213A1

公开(公告)日：2015-04-23

申请号：US13640117

申请日：2011-04-11

Applicant: Helmut Hanenberg ,  Dieter Niederacher ,  Kathrin Irmgara Maria Scheckenbach ,  Rita Schmutzler ,  Alfons Meindl ,  Constanze Wiek ,  Verena Erven ,  Marcel Freund

Inventor： Helmut Hanenberg ,  Dieter Niederacher ,  Kathrin Irmgara Maria Scheckenbach ,  Rita Schmutzler ,  Alfons Meindl ,  Constanze Wiek ,  Verena Erven ,  Marcel Freund

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: The invention discloses in vitro methods and a system for determining a predisposition of a subject for developing a cancer on the basis of analyzing a sample of the subject for an alteration of at least one allele of the RAD51C gene. Further disclosed are in vitro methods for assessing clinical features or a pathological progression of a cancer and for assessing at least one RAD51 C gene alteration in a cell. In addition a kit for determining a predisposition of a subject for developing a cancer, and certain uses of oligonucleotides for determining the presence of at least one mono-allelic germ-line mutation of the RAD51C gene.

Abstract translation: 本发明公开了体外方法和系统，用于在分析用于RAD51C基因的至少一个等位基因的改变的受试者样品的基础上确定受试者的发展癌症倾向。 进一步公开的是用于评估癌症的临床特征或病理进展以及用于评估细胞中至少一种RAD51C基因改变的体外方法。 此外，用于确定受试者用于开发癌症的易感性的试剂盒以及确定存在RAD51C基因的至少一种单等位基因种系突变的寡核苷酸的某些用途。