A pneumatic door system and a method of using the same are disclosed herein. According to one embodiment, a trailer may include a seamless main door and at least one side door. The doors may be configured to be locked shut with a system of pneumatic locks. The main door may be configured to open and close as controlled by pneumatic pressure applied to a door cylinder. The pneumatic system may be configured to be controlled by an interior control box. The pneumatic system may be configured to operate off of pneumatic pressure in an auxiliary air tank, the pressure being protected by a series of one-way check valves. The pneumatic system may also be configured to operate wirelessly using RFID or Bluetooth technology, among other things, to secure the cargo and facilitate ingress and egress to the trailer.