Invention Application
US20150231152A1 FLUOROALKYL AND FLUOROCYCLOALKYL 1,4-BENZODIAZEPINONE COMPOUNDS
有权
氟代烷基和氟代环烷基1,4-二苯并恶嗪酮化合物
- Patent Title: FLUOROALKYL AND FLUOROCYCLOALKYL 1,4-BENZODIAZEPINONE COMPOUNDS
- Patent Title (中): 氟代烷基和氟代环烷基1,4-二苯并恶嗪酮化合物
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Application No.: US14429958Application Date: 2013-09-20
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Publication No.: US20150231152A1Publication Date: 2015-08-20
- Inventor: Yufen Zhao , Ashvinikumar V. Gavai , Patrice Gill , Soong-Hoon Kim , Brian E. Fink , Libing Chen , Mark G. Saulnier , Wen-Ching Han
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- International Application: PCT/US2013/060841 WO 20130920
- Main IPC: A61K31/5513
- IPC: A61K31/5513 ; A61K45/06 ; C07D243/24

Abstract:
Disclosed are compounds of Formula (I): (Formula (I)) wherein: R1 is —CH2CH2CF3; R2 is —CH2CH2CH2F, —CH2CF2CH3, —CH2CH2CF3, —CH2CH(CH3)CF3, —CH2CH2CF2CH3, (Formulae (II), (III), (IV), (V) or (VI): R3 is H or —CH3; Ring A is phenyl or pyridinyl; and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
Public/Granted literature
- US09427442B2 Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds Public/Granted day:2016-08-30
Information query
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