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公开(公告)号：US11370785B2
公开(公告)日：2022-06-28
申请号：US16759782
申请日：2018-10-31
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Joseph E. Carpenter , Jianxin Feng , Ji Jiang , Soong-Hoon Kim , Ying Wang , Gang Wu
IPC: C07D417/14 , C07D401/14 , C07D413/06 , C07D413/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D513/04
Abstract: The present invention provides compounds of Formula (I), or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
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2.发明授权Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase 有权酰胺，尿素或砜酰胺连接苯并噻唑抑制剂的内皮脂肪酶公开(公告)号：US08987314B2
公开(公告)日：2015-03-24
申请号：US13944921
申请日：2013-07-18
Applicant: Bristol-Myers Squibb Company
Inventor： Heather Finlay , Ji Jiang , Soong-Hoon Kim , Brandon Parkhurst , Jennifer X. Qiao , Tammy C. Wang , Zulan Pi , George O. Tora , John Lloyd , James A. Johnson
IPC: C07D277/64 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , A61K31/428 , A61P9/10
CPC classification number: C07D277/64 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US10173991B2
公开(公告)日：2019-01-08
申请号：US15108584
申请日：2015-01-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Zulan Pi , Jennifer X. Qiao , Soong-Hoon Kim , Tammy C. Wang , Ji Jiang , Heather Finlay , John Lloyd
IPC: C07D417/04 , C07D277/64 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used medicaments.
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公开(公告)号：US20160355507A1
公开(公告)日：2016-12-08
申请号：US15171276
申请日：2016-06-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Soong-Hoon Kim , R. Michael Lawrence , Michael C. Myers , Hannguang J. Chao , Monique Phillips , Ji Jiang
IPC: C07D413/04 , C07D417/14 , C07D498/04 , C07D413/14
CPC classification number: C07D413/04 , C07D401/04 , C07D413/14 , C07D417/14 , C07D498/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
Abstract translation: 其中所有变量如说明书中所定义，以及包含任何这些新化合物的组合物。 这些化合物是可用作药物的APJ激动剂。
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公开(公告)号：US09371328B2
公开(公告)日：2016-06-21
申请号：US14191861
申请日：2014-02-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
IPC: C07D487/04 , C07D498/04
CPC classification number: C07D487/04 , C07D498/04
Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑并哒嗪抑制蛋白激酶活性，从而使其成为抗癌剂。
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Patent Agency Ranking
公开(公告)号：US20150284342A1
公开(公告)日：2015-10-08
申请号：US14742158
申请日：2015-06-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ashvinikumar V. Gavai , Claude A. Quesnelle , Soong-Hoon Kim
IPC: C07D243/24
CPC classification number: C07D243/24 , A61K31/138 , A61K31/282 , A61K31/337 , A61K31/506 , A61K31/5513 , A61K31/555 , A61K31/573 , A61K45/06 , A61K2300/00
Abstract: Disclosed are compounds of Formula (I) or prodrugs thereof; wherein: R1 is —CH2CF3 or —CH2CH2CF3; R2 is —CH2CF3, —CH2CH2CF3, or —CH2CH2CH2CF3; R3 is H or —CH3; each Ra is independently F, Cl, —CN, —OCH3, and/or —NHCH2CH2OCH3; and z is zero, 1, or 2. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
Abstract translation: 公开了式（I）的化合物或其前药; 其中：R1是-CH2CF3或-CH2CH2CF3; R2是-CH2CF3，-CH2CH2CF3或-CH2CH2CH2CF3; R3是H或-CH3; 每个R a独立地是F，Cl，-CN，-OCH 3和/或-NHCH 2 CH 2 OCH 3; 并且z为零，1或2.还公开了使用这些化合物抑制Notch受体的方法，以及包含这些化合物的药物组合物。 这些化合物可用于治疗，预防或减缓各种治疗领域（例如癌症）中疾病或病症的发展。
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公开(公告)号：US20150239879A1
公开(公告)日：2015-08-27
申请号：US14427105
申请日：2013-09-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： George O. Tora , Heather Finlay , Carol Hui Hu , Ji Jiang , James A. Johnson , Soong-Hoon Kim , John Lloyd , Brandon Parkhurst , Zulan Pi , Jennifer X. Qiao , Tammy C. Wang
IPC: C07D417/06 , C07D417/14
CPC classification number: C07D417/06 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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8.发明申请AMIDE, UREA OR SULFONE AMIDE LINKED BENZOTHIAZOLE INHIBITORS OF ENDOTHELIAL LIPASE 有权氨基酸，尿素或磺酰胺连接的内皮素的苯并噻唑抑制剂公开(公告)号：US20140045811A1
公开(公告)日：2014-02-13
申请号：US13944921
申请日：2013-07-18
Applicant: Bristol-Myers Squibb Company
Inventor： Heather Finlay , Ji Jiang , Soong-Hoon Kim , Brandon Parkhurst , Jennifer X. Qiao , Tammy C. Wang , Zulan Pi , George O. Tora , John Lloyd , James A. Johnson
IPC: C07D277/64 , C07D417/10 , C07D417/12 , C07D417/04 , C07D417/14
CPC classification number: C07D277/64 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US20190330186A1
公开(公告)日：2019-10-31
申请号：US16309168
申请日：2017-06-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ji Jiang , Heather Finlay , Soong-Hoon Kim , Wei Meng , George O. Tora
IPC: C07D401/12 , C07D221/00 , C07D401/14 , C07D471/04 , C07D413/14
Abstract: The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US10392347B2
公开(公告)日：2019-08-27
申请号：US15767364
申请日：2016-10-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Soong-Hoon Kim , Hannguang J. Chao , Heather Finlay , Ji Jiang , James A. Johnson , R. Michael Lawrence , Michael C. Myers , Monique Phillips , George O. Tora , Wei Meng
IPC: C07D213/82 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/107 , C07D498/10 , C07D401/12 , C07D471/10
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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