发明申请
US20150232570A1 Methods of Treating Hematological Malignancies with Notch1 Antibodies
审中-公开
用Notch1抗体治疗血液恶性肿瘤的方法
- 专利标题： Methods of Treating Hematological Malignancies with Notch1 Antibodies
- 专利标题（中）： 用Notch1抗体治疗血液恶性肿瘤的方法
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申请号： US14429497申请日： 2013-09-20
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公开(公告)号： US20150232570A1公开(公告)日： 2015-08-20
- 发明人: Timothy C. Hoey , Ann M. Kapoun , Min Wang , Tzu-Ling Tang Lin , Jennifer Anne Cain , Jakob Dupont
- 申请人： Oncomed Pharmaceuticals, Inc.
- 申请人地址： US CA Redwood City
- 专利权人： ONCOMED PHARMACEUTICALS, INC.
- 当前专利权人： ONCOMED PHARMACEUTICALS, INC.
- 当前专利权人地址： US CA Redwood City
- 国际申请： PCT/US2013/060878 WO 20130920
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; A61K45/06 ; C12Q1/68 ; A61K39/395
摘要：
NOTCH1-binding antibodies and methods of using the antibodies for treating hematologic cancers are disclosed. Methods of using antibodies that bind to a non-ligand binding membrane proximal region of the extracellular domain of human NOTCH1 and methods of treating chronic lymphocytic leukemia (CLL), hairy cell leukemia, chronic myelogenous leukemia (CML), nonHodgkin lymphoma, diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), or cutaneous T-cell lymphoma (CTCL) in a subject, comprising administering a therapeutically effective amount of a NOTCH1-binding antibody to the subject are also disclosed. Methods of identifying subjects suitable for such treatment methods are further disclosed.
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