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公开(公告)号：US10232017B2
公开(公告)日：2019-03-19
申请号：US15636711
申请日：2017-06-29
发明人： Austin L Gurney
IPC分类号： A61K38/19 , C12Q1/68 , C07K14/00 , C07K14/52 , C07K16/18 , C12N15/00 , C12N15/62 , C07K14/525 , C07K14/715 , A61K39/395 , A61K45/06 , A61K39/00 , A61K39/295
摘要： Polypeptides and agents that bind a TNF receptor superfamily protein are disclosed, particularly agents that specifically bind GITR, OX40, or CD40. The polypeptides or agents may include fusion polypeptides, particularly polypeptides comprising GITRL, OX40L, or CD40L and/or bispecific agents. Also disclosed are methods of using the polypeptides or agents for inducing and/or enhancing the immune response, as well as methods for the treatment of diseases such as cancer.
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公开(公告)号：US20190048094A1
公开(公告)日：2019-02-14
申请号：US16079180
申请日：2017-02-24
IPC分类号： C07K16/30 , C07K14/005 , A61K39/395 , A61K45/06
摘要： Agents that specifically bind tumor-associated antigens (TAA) and comprise an exogenous polypeptide or peptide that can be presented by a tumor cell are disclosed. The TAA-binding agents may include antibodies and/or bispecific agents. Also disclosed are methods of using the agents for redirecting an existing immune response against tumor cells and/or treatment of diseases such as cancer.
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3.发明申请公开(公告)号：US20180346556A1
公开(公告)日：2018-12-06
申请号：US15966247
申请日：2018-04-30
IPC分类号： C07K16/18 , A61K39/395 , A61K31/166 , A61K31/341 , A61K31/401 , A61K31/4184 , A61K31/4418 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , A61K31/138 , A61K39/00 , C07K16/22 , C07K16/24
CPC分类号： C07K16/18 , A61K31/138 , A61K31/166 , A61K31/341 , A61K31/401 , A61K31/4184 , A61K31/4418 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , Y10S530/80 , Y10S530/86 , A61K2300/00
摘要： Methods for treating cancer comprising administering a DLL4 antagonist and one or more anti-hypertensive agents are described. Also described are pharmaceutical compositions comprising a DLL4 antagonist and one or more anti-hypertensive agents, and kits comprising the same.
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公开(公告)号：US20180222958A1
公开(公告)日：2018-08-09
申请号：US15849368
申请日：2017-12-20
IPC分类号： C07K14/525 , C07K16/28 , A61K38/19 , A61P35/00 , A61K45/06
CPC分类号： C07K14/5255 , A61K38/00 , A61K38/191 , A61K45/06 , A61K2039/505 , A61P35/00 , C07K16/28 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2319/00 , C07K2319/30 , C07K2319/74 , Y02A50/465
摘要： Polypeptides, agents, and molecules that bind lymphotoxin-beta receptor (LTβR) and/or tumor-associated antigens are disclosed. The polypeptides, agents, or molecules may include, without limitation, fusion or single-chain lymphotoxin-αββ polypeptides and homodimer and heterodimer molecules comprising the lymphotoxin-αββ polypeptides. Antibodies that specifically bind B7-H4 and P-CADHERIN are also disclosed. Also disclosed are methods of using the polypeptides, agents, molecules, or antibodies for inducing and/or enhancing the immune response, as well as methods for the treatment of diseases such as cancer.
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公开(公告)号：US20180214526A1
公开(公告)日：2018-08-02
申请号：US15797182
申请日：2017-10-30
IPC分类号： A61K39/00 , A61K45/06 , A61K38/17 , C07K14/705 , A61K38/19
CPC分类号： A61K39/0005 , A61K38/177 , A61K38/1774 , A61K38/19 , A61K45/06 , C07K14/705 , Y02A50/465 , A61K2300/00
摘要： Binding agents that modulate the immune response are disclosed. The binding agents may include soluble receptors, polypeptides, and/or antibodies. Also disclosed are methods of using the binding agents for the treatment of diseases such as cancer.
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公开(公告)号：US09987357B2
公开(公告)日：2018-06-05
申请号：US15147521
申请日：2016-05-05
发明人： Jakob Dupont , Robert J. Stagg
IPC分类号： A61K38/17 , G01N33/68 , A61K39/395 , C07K16/30 , A61K31/675 , C07K16/28 , A61K45/06 , G01N33/574 , A61K39/00 , C07K14/72
CPC分类号： A61K39/39558 , A61K31/675 , A61K38/177 , A61K39/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/545 , A61K2039/585 , C07K14/723 , C07K16/2863 , C07K16/2869 , C07K16/2875 , C07K16/30 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2319/30 , G01N33/574 , G01N33/6887 , G01N2333/78 , G01N2800/108 , G01N2800/52 , G01N2800/7028 , A61K2300/00
摘要： Methods for treating diseases such as cancer comprising administering a Wnt pathway inhibitor, either alone or in combination with other anti-cancer agents, and monitoring for skeletal-related side effects and/or toxicity.
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公开(公告)号：US09914771B2
公开(公告)日：2018-03-13
申请号：US15059668
申请日：2016-03-03
发明人： Austin L. Gurney , Aaron K. Sato
IPC分类号： C07K16/22 , A61K39/395 , A61K51/10 , A61K45/06 , C07K16/18 , C07K16/46 , C12N15/00 , A61K39/00 , A61K47/68
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K51/1021 , A61K2039/505 , C07K16/18 , C07K16/468 , C07K2317/20 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/55 , C07K2317/565 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C12N15/00
摘要： Methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising these molecules are disclosed. The methods include introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered.
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公开(公告)号：US20170267776A1
公开(公告)日：2017-09-21
申请号：US15439288
申请日：2017-02-22
CPC分类号： C07K16/30 , A61K39/39533 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/03 , C07K2319/30 , C07K2319/32 , C07K2319/60 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , A61K2300/00
摘要： The present invention relates to RSPO-binding agents, particularly RSPO3-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO3 proteins and modulate β-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO3 proteins and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
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公开(公告)号：US20170266276A1
公开(公告)日：2017-09-21
申请号：US15531876
申请日：2015-12-02
IPC分类号： A61K39/385 , A61K39/395 , A61K39/44 , A61K39/00
CPC分类号： A61K39/385 , A61K31/337 , A61K31/357 , A61K31/427 , A61K31/475 , A61K39/0011 , A61K39/39558 , A61K39/39591 , A61K39/44 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61P35/00 , C07K16/18 , C07K2317/22 , C07K2317/24 , C07K2317/30 , C07K2317/32 , A61K2300/00
摘要： Described herein are combination therapies for the treatment of cancer and other diseases. In one aspect, the methods described herein for the treatment of cancer and other diseases comprise administering an RSPO-LGR pathway inhibitor in combination with a mitotic inhibitor.
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公开(公告)号：US20170183405A1
公开(公告)日：2017-06-29
申请号：US15291334
申请日：2016-10-12
IPC分类号： C07K16/28 , A61N5/10 , A61K45/06 , C07K16/30 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
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